Accepted Manuscript Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens Alessia Salamone, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Paula Agostinho, Angelo R. Tomé, Jiayang Chen, Anna Pittaluga, Rodrigo A. Cunha, Mario Marchi PII: S0028-3908(13)00592-3 DOI: 10.1016/j.neuropharm.2013.12.014 Reference: NP 5347 To appear in: Neuropharmacology Received Date: 1 August 2013 Revised Date: 20 November 2013 Accepted Date: 14 December 2013 Please cite this article as: Salamone, A., Zappettini, S., Grilli, M., Olivero, G., Agostinho, P., Tomé, A.R., Chen, J., Pittaluga, A., Cunha, R.A., Marchi, M., Prolonged nicotine exposure down- regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens, Neuropharmacology (2014), doi: 10.1016/j.neuropharm.2013.12.014. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.