ANTIHELMINTIC EFFECT OF EMBELIA TSJERIAM-COTTAM Manjusha Suresh Nikam 1 , Md. Rageeb Md. Usman * , Gautam P. Vadnere 1 *1 Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India ABSTRACT The present study was undertaken to investigate the anthelmintic activity of extract of Embeliatsjeriam-cottam using earthworm. Different concentrations of standard drug (Albendazole) and extract of Embeliatsjeriam-cottam fruits were employed and the average time required for paralysis and death was noted. It was found that the Paralysis time & Death time was lowest for 5% concentration of Ethanolic extract and Death time was slightly better than Albendazole Standard solution. Though Ethanolic Extract can be compared to the Standard hence establishing the pharmacological antihelminthic activity of Embelia tsjeriam- cottam. Keywords:Embelia tsjeriam-cottam Anthelmintic Activity, Albendazole, Ethanolic Extract. INTRODUCTION Helminthes infections are among the most widespread infections in humans, distressing a huge population of the world. The human roundworm A. lumbricoides is one of the most common parasites in the world, infecting 1.2 billion people globally. Infections are most commonly documented in Asia, sub-Saharan Africa, the Americas and China. The spectrum of disease associated with A. lumbricoides infection is known as ascariasis, and morbidity assessed as disability adjusted life years (DALYs) is approximately 10.5 million. Furthe rmore, morbidity with serious health consequences is observed in 122 million cases per year [1,2] The World Health Organization reports that 35% diseases are because of roundworm, which is a typical parasitic worm. More than 1.5 billion individuals or 24% of the total population are tainted with soil-transmitted (STH) helminth contaminations around the world. [3] However, ascariasis is still considered a neglected tropical disease (NTD). The community-based control of STHs is based on mass drug administration by two synthetic anthelmintics, albendazole and mebendazole. [4] A wide spread resistance to the commercially available anthelmintic treatments has been observed in multiple nematode species. [5] Therefore, alternative anthelmintic strategies are urgently needed. In addition anthelmintic strategies such as grazing management, biological control with nematophagous fungi or food supplementation with leguminous plants accumulating high amounts of condensed tannins, phytotherapy could be a part of an integrated control system. The family Journal of University of Shanghai for Science and Technology ISSN: 1007-6735 Volume 23, Issue 6, June - 2021 Page -826