Accepted Manuscript Title: Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality Author: Eric Karengera Anna Robotham John Kelly Yves Durocher Gregory De Crescenzo Olivier Henry PII: S0168-1656(16)31637-6 DOI: http://dx.doi.org/doi:10.1016/j.jbiotec.2016.12.003 Reference: BIOTEC 7741 To appear in: Journal of Biotechnology Received date: 12-7-2016 Revised date: 29-11-2016 Accepted date: 1-12-2016 Please cite this article as: Karengera, Eric, Robotham, Anna, Kelly, John, Durocher, Yves, De Crescenzo, Gregory, Henry, Olivier, Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality.Journal of Biotechnology http://dx.doi.org/10.1016/j.jbiotec.2016.12.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.