CLINICAL PRACTICE ARTICLE Functional and non-functional types of adrenal tumors: a case series [version 1; peer review: 1 not approved] Dwiki Haryo Indrawan 1 , Fauriski Febrian Prapiska 2 , Syah Mirsya Warli 3 , Bungaran Sihombing 2 , Ginanda Putra Siregar 2 1 Urology, Faculty of Medicine Universitas Indonesia- Cipto Mangunkusumo National Hospital, Jakarta, DKI Jakarta, Indonesia 2 Urology Division Of Surgery Department, Faculty of Medicine Universitas Sumatera Utara - H. Adam Malik General Hospital, Medan, Sumatera Utara, 20136, Indonesia 3 Urology, Faculty of Medicine - Universitas Sumatera Utara General Hospital, Medan, Sumatera Utara, Indonesia First published: 28 Jul 2021, 10:675 https://doi.org/10.12688/f1000research.51593.1 Latest published: 28 Jul 2021, 10:675 https://doi.org/10.12688/f1000research.51593.1 v1 Abstract Adrenal gland masses could be classified into functional, malignant, or benign. An adrenal cortical adenoma is one of the most common incidentalomas found with either functional or non-functional type. Pheochromocytoma is a neural crest cell origin tumor associated with catecholamine production. A classic triad of headache, sudden episodic perspiration, and tachycardia marked a pheochromocytoma. We report three patients with adrenal tumors. First, a 52-year-old woman with complaints of pain in the left flank suggests a left kidney tumor. The patient has an increased blood pressure intraoperatively. Adrenal cortical adenoma was found postoperatively. The second case is an Indonesian male 27-year-old with pain in the upper right abdomen. Intraoperative, the patient also has an escalation in blood pressure. Antihypertensive drugs are also used in this patient. Postoperatively, a pathology result of pheochromocytoma was revealed from this patient. The third case, adrenal myelolipoma, was suspected in a 48-year-old male and underwent surgery because of tumor growth. Later, a histopathological examination revealed myelolipoma of the adrenal. Management of adrenal tumor should be done individually based on each patient. In the first and second cases, blood pressure was unstable intraoperatively and was managed using several drugs, and was stable at follow-up. In the third case was no hemodynamic problem. In the case of an adrenal tumor, management tailoring should be based on the individual patient. Keywords Adrenal cortical adenoma, adrenal tumor, pheochromocytoma, adrenal myelolipoma Open Peer Review Approval Status 1 version 1 28 Jul 2021 view Christina Pamporaki , University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany MKIII, Universitätsklinikum Carl Gustav Carus, Dresden, Germany 1. Any reports and responses or comments on the article can be found at the end of the article. Page 1 of 11 F1000Research 2021, 10:675 Last updated: 24 FEB 2023