Citaton: Ahmed M, Arsalan, Chaudhary B, Rehman A, Khan F, Sultan A. Protocol based Surgical Antmicrobial Prophylaxis in Endo-Urologic Surgeries: An Atempt to Convince the Surgeons to Follow the Guidelines. J Pure Appl Microbiol. 2023;17(1):627- 635. doi: 10.22207/JPAM.17.1.60 © The Author(s) 2023. Open Access. This artcle is distributed under the terms of the Creatve Commons Atributon 4.0 Internatonal License which permits unrestricted use, sharing, distributon, and reproducton in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creatve Commons license, and indicate if changes were made. Ahmad et al. | Artcle 8032 J Pure Appl Microbiol. 2023;17(1):627-635. doi: 10.22207/JPAM.17.1.60 Received: 16 August 2022 | Accepted: 22 February 2023 Published Online: 03 March 2023 RESEARCH ARTICLE OPEN ACCESS www.microbiologyjournal.org 627 Journal of Pure and Applied Microbiology P-ISSN: 0973-7510; E-ISSN: 2581-690X *Correspondence: fatmasalmanshah@gmail.com Protocol based Surgical Antmicrobial Prophylaxis in Endo-Urologic Surgeries: An Atempt to Convince the Surgeons to Follow the Guidelines Manzoor Ahmad 1 , Arsalan 2 , Bhanu Chaudhary 2 , Atq-ur Rehman 1 , Fatma Khan 3 * and Asfa Sultan 3 1 Department of Surgery, Jawaharlal Nehru Medical College and Hospital, Aligarh, Utar Pradesh, India. 2 Jawaharlal Nehru Medical College and Hospital, Aligarh, Utar Pradesh, India. 3 Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh, Utar Pradesh, India. Abstract Surgical antbiotc prophylaxis (SAP) prevents infectous complicatons during surgery by administering an efectve antmicrobial agent before surgery. There is, however, lack of adherence to the standard SAP administraton protocol. We reviewed 576 surgeries and fnd that cefuroxime/cefazolin was used as SAP in less than 31% of surgeries followed by cefriaxone and cefoperazone. In 61% of cases, SAP was contnued for more than 24 hours and in 2/3rd more than one SAP was prescribed, we noted the best SAP compliance was for the tming of pre-operatve dosage. We then selected a unit of urology and applied the recommended SAP protocol, and monitored the patent’s outcome. All the surgeries were endoscopic urological procedures and our protocol was efectve in 97.7% of patents. Out of 89, 78(87.6%) surgeries went uneventul, whereas 11 (12.4%) had post-operatve complicatons. Two out of 89 (2.2%) cases had UTI post-operatvely which was considered as surgical site infecton. following the EAU guidelines for antbiotc prophylaxis reduced antbiotc use without increasing postoperatve infecton rates and SAP should be followed as per the standard guidelines in other units also. This small study is a way forward for our HICC team to motvate other surgeons to follow the guidelines and become antmicrobial stewardship champions. Our study demonstrates the feasibility of developing and successfully implementng such protocols. Keywords: Surgical Antbiotc Prophylaxis, Surgical Site Infecton, Urologic Surgical Procedures, Antmicrobial Resistance, Antbiotc Stewardship