Vinoth Kanna S et al., Int. J. Res. Pharm. Sci., 2021, 12(1), 699-702 ORIGINAL ARTICLE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps A Study On Assessment Of Autonomic Nervous System Function In Patients With Type 2 Diabetes Mellitus Sharath shanmugam 1 , Oshin mantro 1 , Jagadeesan M 1 , Mariraj I 1 , Prasanna Karthik S 1 , Gowrishankar 1 , Magesh Kumar 1 , Vinoth Kanna S *2 1 Department of General Medicine, Saveetha Medical College and Hospital, SIMATS Thandalam Chennai, Tamilnadu – 602105, India 2 Department of Neurology, Saveetha Medical College and Hospital, Chennai SIMATS Thandalam, Tamilnadu – 602105, India Article History: Received on: 01 Sep 2020 Revised on: 20 Sep 2020 Accepted on: 01 Oct 2020 Keywords: Diabetes mellitus (DM), Autonomic nervous system (ANS), cardiac autonomic neuropathy (CAN), Diabetic autonomic neuropathy (DAN) ABSTRACT The autonomic nervous system (ANS) innervates the entire neuraxis and inϑlu- ences the functions of all organs. This study was undertaken for evaluat- ing the autonomic dysfunction in diabetic patients using clinical autonomic tests and neuro- electrophysiology. A prospective study was carried out in 66 patients with type II diabetes mellitus in a tertiary care hospital for one year. Systemic examination, necessary investigations, nerve conduction study and clinical testing for the autonomic nervous system were done. The results were noted and analyzed. 65.2% were females, whereas 34.8% were males. Mean duration of diabetes was found to be 9.06 years (SD 4.121). 80.3% pop- ulation was known to have type 2 diabetes for 5-10 years duration, 13.6% had diabetes for 10-15 years, and only 3.5% had diabetes for more than 15 years. Mean FBS was found to be 196.12(mg/dl) ±77.180 SD and mean PPBS was 303.26(mg/dl) ± 115.385 SD. Mean HbA1c levels were 10.95 ± 2.36 SD. 33.3% showed early parasympathetic involvement for cardiac autonomic neu- ropathy, 9% had deϑinite parasympathetic involvement, and only 6% had both parasympathetic and sympathetic involvement. 62.12% showed abnormal responses in nerve conduction study, of which 48.78% had autonomic dys- function. The main factor responsible for the development and progression of autonomic dysfunction is poor glycaemic status. If contributing factors can be detected, early identiϑication of cardiac autonomic neuropathy (CAN) and appropriate management would halt its progression. Aggressive glycaemic monitoring and treatment shall bring down the progression and prolong the time interval in showing abnormal responses in autonomic function testing. * Corresponding Author Name: Vinoth Kanna S Phone: 9443490272 Email: svkanna2006@yahoo.co.in ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v12i1.4163 Production and Hosted by Pharmascope.org © 2021 | All rights reserved. INTRODUCTION The autonomic nervous system (ANS) innervates the entire neuraxis and inϑluences all organ sys- tems. The autonomic nervous system regulates blood pressure, heart rate, sleep, bowel and blad- der functions. The activity of the ANS is regulated by central neurons responsive to diverse afferent input. After the central integration of afferent infor- mation, the autonomic outϑlow is adjusted to per- mit the functioning of the major organ system per the need of the organism. The cerebral cortex, in © International Journal of Research in Pharmaceutical Sciences 699