Accepted Manuscript Characterizing Drug Product Continuous Manufacturing Residence Time Dis- tributions of Major/Minor Excipient Step Changes using Near Infrared Spec- troscopy and Process Parameters Leo Manley, Zhenqi Shi PII: S0378-5173(18)30646-X DOI: https://doi.org/10.1016/j.ijpharm.2018.08.059 Reference: IJP 17745 To appear in: International Journal of Pharmaceutics Received Date: 13 June 2018 Revised Date: 10 August 2018 Accepted Date: 31 August 2018 Please cite this article as: L. Manley, Z. Shi, Characterizing Drug Product Continuous Manufacturing Residence Time Distributions of Major/Minor Excipient Step Changes using Near Infrared Spectroscopy and Process Parameters, International Journal of Pharmaceutics (2018), doi: https://doi.org/10.1016/j.ijpharm.2018.08.059 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.