EAU impose more restrictions in offering TTh to patients with cardiovascular disease. Notably, the AUA recommends against TTh if patients experienced a cardiovascular event within the past 3- 6 months, while the EAU states that TTh is contraindicated in patients with NYHA Class IV heart failure. In contrast, the CMAJ recommends TTh in patients with stable cardiovascular disease. CONCLUSIONS: While there is consensus among current guidelines on TD, notable differences may impact diagnosis and eligi- bility for TTh. Additional work is needed to consolidate recommenda- tions across guidelines, especially for specific patient populations. We highlight the limitations of relying exclusively on guidelines in managing patients with TD. Source of Funding: None MP40-06 ASSESSING THE ABILITY OF THE MALE ANDROGEN DEFICIENCY SYNDROME (MADS) SCREENING QUESTIONNAIRE TO PREDICT HYPOGONADISM Shivaram Cumarasamy*, Shirin Razdan, Jared Winoker, New York City, NY; Wendy Poage, Centennial, CO; E. David Crawford, Aurora, CO; Nelson Stone, New York City, NY INTRODUCTION AND OBJECTIVES: To assess and validate the ability of a previously designed simplified screening questionnaire (MADS) to predict hypogonadism in men. METHODS: 1043 men who filled out the MADS questionnaire were analyzed, all of whom had complete data regarding questionnaire completion, age, and testosterone levels. A positive screen was defined as at least one question being answered in the affirmative. Mean testosterone levels were compared between participants for each question. Sensitivity and specificity analyses were performed for a positive screen in predicting hypogonadism (T<300ng/dL). Age and a positive MADS screen were explored as covariates in univariate and multivariate logistic regression models to predict the odds of having hypogonadism. RESULTS: Overall, 452 (43.3%) men had T<300ng/dL. A total of 92 (8.9%) men had a positive screen on the MADS questionnaire. Forty (3.8%), 39 (3.7%), and 34 (3.3%) men answered yes to questions 1, 2, and 3, respectively. The differences in testosterone levels between patients who answered yes or no to each question are listed in Table 1. Sensitivity and specificity of the questionnaire were 12.4% and 93.9%, respectively. The results of a multivariate logistic regression to predict low testosterone demonstrated that men with a positive MADS screen were significantly more likely to have hypogonadism (OR: 2.19, CI 1.41, 3.40, p[0.00) compared to those that did not have a positive screen (Table 2). CONCLUSIONS: Logistic regression shows a significant ability to predict likelihood of hypogonadism in men with a positive MADS screen. The MADS questionnaire is a simplified and easy to administer screening tool that can be incorporated into the primary care setting. Source of Funding: PCEC MP40-07 THE PREDICTIVE EFFECT OF FREE TESTOSTERONE ON SEXUAL FUNCTION INCREASES WITH AGE Maxwell Towe*, Linda M. Huynh, Farouk M. El-Khatib, Faysal A. Yafi, Thomas Ahlering, Orange, CA INTRODUCTION AND OBJECTIVES: While the impacts of age and testosterone on sexual function have been well-studied, the additive relationship of these three variables has seldom been mentioned. In the present study, we seek to assess the impact of testosterone and age on baseline sexual function in men with prostate cancer. METHODS: We retrospectively reviewed 850 patients who presented for primary treatment of prostate cancer between December 2009 and June 2018. Preoperative sexual function was measured via the International Index of Erectile Function-5 (IIEF-5). Total and free testosterone (FT and TT) were collected and calculated preoperatively in 822 patients. To assess the impact of age, patients were stratified patients by decade of life and the most predictive cut- off was determined to be at 60 years of age. Univariate and multivariate analyses were conducted to assess impact of FT, TT, age, Body Mass Index (BMI), and pathological grade on sexual function. RESULTS: Overall, 822 patients were included, of which 35.4% (291/822) were <60 years. Mean FT was significantly higher in the <60 aged cohort (6.744.24 ng/dL) vs. the >60 aged cohort (5.62.52 ng/dL), (p<0.001). In multivariate analysis, FT was only an independent predictor of IIEF-5 scores for patients >60 years old (p[0.018), but not in patients younger than 60 (p[0.69). Similarly, BMI was not significantly correlated with sexual function in younger men (<60 years old) (p>0.05), but was an independent predictor in the older cohort (p<0.001). Age was an e588 THE JOURNAL OF UROLOGY Ò Vol. 201, No. 4S, Supplement, Saturday, May 4, 2019 Copyright © 2019 American Urological Association Education and Research, Inc. Unauthorized reproduction of this article is prohibited.