International Journal of Research in Medical Sciences | January 2020 | Vol 8 | Issue 1 Page 367 International Journal of Research in Medical Sciences Monteiro R et al. Int J Res Med Sci. 2020 Jan;8(1):367-370 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Case Report Extrarenal angiomyolipoma in uterine cervix: rare presentation in unusual site Rashmi Monteiro 1 , Shikha Sharma 2 , Sonal Gupta 3 *, Indu Choudhary 1 INTRODUCTION Angiomyolipoma is a benign neoplasm composed of variable admixture of blood vessels, smooth muscle cells and adipose tissue. It occurs most frequently in the kidney where it is closely associated with tuberous sclerosis and occasionally in extrarenal sites, most commonly liver, but occurrence at other sites is extremely rare. 1-3 Many cases of extra-renal angiomyolipoma have been reported in various organs like the liver, pelvic region, retroperitoneum (not connected to kidney), uterus, somatic soft tissue, large bowel, nasal cavity and bone. Few cases of extra-renal angiomyolipoma have been reported in the female genital tract among which uterus is the most common site. Cervical angiomyolipoma without concurrent incidence in the kidney is extremely rare and only four cases of angiomyolipoma in cervix have been reported in the literature till date. 4 Herein author report a case of angiomyolipoma, occurring in uterine cervix in a 43 years old female. CASE REPORT A 43 years old female presented with complaints of mass descending per vagina for 6 months in the gynaecology OPD. The patient was P2L2, sterilized, last childbirth was 1 Department of Pathology, Pacific Medical College and Hospital, Udaipur, Rajasthan, India 2 Department of Pathology, NC Medical College and Hospital, Panipat, Haryana, India 3 Department of Pathology, NM Medical, Khar, Mumbai, India Received: 20 October 2019 Revised: 15 November 2019 Accepted: 20 November 2019 *Correspondence: Dr. Sonal Gupta, E-mail: sonalomprakashgupta@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Angiomyolipoma is a benign neoplasm composed of variable admixture of blood vessels, smooth muscle cells and adipose tissue. Cervical angiomyolipoma are extremely rare and to the best of our knowledge only five cases of angiomyolipoma in cervix have been reported in the literature till date. Authors are presenting a case of angiomyolipoma arising from the uterine cervix. 43 years old female presented with mass descending per vagina for 6 months. This case had no association with tuberous sclerosis. Microscopic examination showed an ill-defined polypoidal, non-encapsulated lesion covered by keratinized stratified epithelium. The lesion is made up of three components, predominantly by fascicles of spindle shaped cells, varying sized blood vessels and multiple foci of mature adipocytes with no evidence of atypia or increased mitotic activity. Smooth muscle component showed strong immunoreactivity to SMA and absence of elastic fibres in the blood vessels were confirmed by histochemistry. Non- vascular smooth muscle cells were negative for HMB-45 in contrast to renal and other extra-renal angiomyolipoma in which HMB-45 immunoreactivity in seen in these cells. To conclude, the differential diagnosis of lower abdominal mass and dysfunctional uterine bleeding should include the angiomyolipoma, even though the uterine cervix is an extremely rare location where they occur. Keywords: Angiomyolipoma, Female genital tract, Histochemistry, Immunohistochemistry DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20195936