Copyright@ Ekaterina Gormolysova | Biomed J Sci & Tech Res | BJSTR. MS.ID.006581. 32565 Research Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2022.41.006581 Prevalence of Diabetes Insipidus and Other Complications in Early Period After Pituitary Surgery: Analysis of 259 Patients Ekaterina Gormolysova 1 *, Jamil Rzaev 1,2 , Ani Karapetyan 1 , Eugeniy Galushko 1 , Eugeniya Amelina 2 and Galina Moisak 1,2 1 Federal Center of Neurosurgery, Russia 2 Institute of Medicine and Psychology, Novosibirsk State University, Russia *Corresponding author: Ekaterina Gormolysova, Federal Center of Neurosurgery, Nemirovich-Danchenko str. 132/1, Novosibirsk, Russia Introduction Pituitary adenomas constitute about 10-12% of all intracranial tumors [1,2]. They are benign tumors growing from adenohypophyseal cells. All adenomas are classified according to their hormonal activity as non-secreting and secreting (prolactinoma, growth hormone-secreting, ACTH-secreting and thyroid stimulation hormone-producing) adenomas. The treatment of choice for most patients with secreting adenomas is surgical removal. In case of prolactinomas, dopamine agonists can be prescribed first. Surgery can be an option in this case if the conservative treatment is unsuccessful [1]. Patients with non- secreting adenomas and any neurological or vision deficit are also candidates for surgery. The most common surgical technique for ARTICLE INFO ABSTRACT Received: January 18, 2022 Published: January 25, 2022 Citation: Ekaterina Gormolysova, Jamil Rzaev, Ani Karapetyan, Eugeniy Galushko, Eugeniya Amelina, Galina Moisak. Prev- alence of Diabetes Insipidus and Other Complications in Early Period After Pitui- tary Surgery: Analysis of 259 Patients. Bi- omed J Sci & Tech Res 41(2)-2022. BJSTR. MS.ID.006581. Keywords: Endoscopic; Pituitary Adeno- mas; Complications; Diabetes Insipidus Objective: The purpose of this study was to describe complications associated with the endoscopic transsphenoidal approach and to determine a relation between postoperative central diabetes insipidus (DI) and the characteristics of adenomas. Methods: 259 patients with adenomas had been selected for our study. All the complications were divided into two groups: surgical complications and DI. Results: Of the 259 patients 159 had non-secreting adenomas, 83 - growth- hormone secreting adenomas, 5 – prolactinomas; 9 patients developed Cushing’s disease, 2 - thyreotropinoma and 1 patient had mixed adenoma (growth-hormone and ACTH-secreting). Most common were macroadenomas, followed by giant adenomas and microadenomas. The overall rate of surgical complications was 13.1%. Some of them had two or more complications. The overall rate of diabetes insipidus (DI) was 42.9% (34.8% - permanent and 8.1% - transient DI). Conclusions: The complications after endoscopic surgery are rather common and include two big groups: surgical and endocrine complications. In multivariate analysis the predictors of DI were patient’s age, size and consistency of adenomas. The older a patient the greater effect the tumor size had on the risk of developing DI. In young patients the risk of DI was 1.51 times higher with increasing of tumor size by one grade in while in elder patients it was 2.3 times higher. The tight consistency of tumor was another important factor the patients developed DI after surgery. The unsuctionable consistency increased risk of DI in 2.89 times.