1 Effects of Orthopedic Manual Therapy on Pain Sensitization in Patients with Chronic Musculoskeletal Pain: An Umbrella Review with Meta-Meta- Analysis Oliver Martínez-Pozas 1 , Eleuterio A. Sánchez-Romero 2-5 , Héctor Beltran-Alacreu 6 , Alberto Arribas-Romano 1,7 , Ferran Cuenca-Martínez 8, *, Jorge Hugo Villafañe 9 & Josué Fernández- Carnero 3,5,7,10,11 1. Escuela Internacional de Doctorado. Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine. Universidad Rey Juan Carlos, 28933 Alcorcón, Spain. 2. Department of Physiotherapy, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain 3. Musculoskeletal Pain and Motor Control Research Group, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain 4. Department of Physiotherapy, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 La Orotava, Spain 5. Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 Tenerife, Spain 6. Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursing. Universidad Castilla La Mancha, 45071 Toledo, Spain. 7. Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Madrid, Spain. 8. Department of Physiotherapy, University of Valencia, 46010, Valencia, Spain. Copyright © 2023 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. American Journal of Physical Medicine & Rehabilitation Articles Ahead of Print DOI: 10.1097/PHM.0000000000002239 ACCEPTED Downloaded from http://journals.lww.com/ajpmr by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1A WnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC1y0abggQZXdgGj2MwlZLeI= on 03/14/2023