Lokesh Kumar et al, International Journal of Pharmaceutical Sciences & Medicine (IJPSM), Vol.8 Issue. 4, April 2023, pg. 110-131 ISSN: 2519-9889 Impact Factor: 5.9 © 2023, IJPSM All Rights Reserved, https://ijpsm.com/ 110 Evaluation of Anti-Inflammatory Activity of Gum Resin Extract of Boswellia Serrata Lokesh Kumar 1 ; Rinkee Verma 1 ; Gurdeep Sharma 2 ; Anamika Nishad 2 ; Sagar Sharma 3 Shri Shankaracharya Institute of Pharmaceutical Sciences and Research 1 Rungta College of Pharmaceutical Sciences and Research, Raipur, C.G. (India) 1 Apollo College of Pharmacy, Anjora, C.G. (India) 2 Bharti University, Durg, C.G. (India) 2 Apollo College Of Pharmacy, Anjora, C.G. (India) 3 DOI: 10.47760/ijpsm.2023.v08i04.009 ABSTRACT: The present investigations of gum resin extract of Boswellia Serrata were studied against experimentally anti-inflammatory activity studies. The work demonstrates that ethanolic gum resin extract and aqueous gum resin extract of Boswellia Serrata has anti-inflammation activity in mice and rat by carrageenan-induced inflammation and cotton pellet-induced granuloma. From the above observations we can conclude that ethanolic extracts and aqueous fum resin extract of Boswellia Serrata anti-inflammatory activity at both the dose level which is comparable with the standard. The ethanolic gum resin extract of Boswellia Serrata (200mg/kg), markedly increased the percentage of average mean increased in paw volume and weight in cotton pellet by the animals. The anti-inflammatory effect of both the doses (150-200 mg/kg in mice and 200-250 mg/kg in rat) showed significant activity and being that (200 mg/kg) showed higher activity. The inflammatory effects of ethanolic extract and aqueous gum resin extract of Boswellia Serrata may be attributed to any of or combination of chemicals present in the extract. Further studies are required to identify the active phytoconstituents responsible for the observed inflammatory effect of ethanol extract and aqueous extract. It is suggested and assumed that a further exploration of the present research work is needed to come up with an active anti- inflammatory. Keywords: Boswellia Serrata, mice, anti-inflammatory, phytoconstituents