MACULAR FUNCTIONAL CHANGES EVALUATED WITH MP-1 MICROPERIMETRY AFTER INTRAVITREAL BEVACIZUMAB FOR SUBFOVEAL MYOPIC CHOROIDAL NEOVASCULARIZATION One-Year Results ANDREA SCUPOLA, MD, ALESSANDRA C. TIBERTI, MD, PHD, PAOLA SASSO, MD, MARIA C. SAVASTANO, MD, ALESSANDRA MASTROCOLA, MD, DARIO MARANGONI, MD, ANGELO M. MINNELLA, MD, BENEDETTO FALSINI, MD, EMILIO BALESTRAZZI, MD Purpose: The purpose of this study was to evaluate 1-year functional and structural effects of intravitreal bevacizumab for subfoveal choroidal neovascularization secondary to pathologic myopia (myopic choroidal neovascularization). Methods: Fifteen eyes with myopic choroidal neovascularization participated in this prospective interventional, noncomparative case series. All patients were treated with one intravitreal injection of 1.25 mg bevacizumab. Retreatments were performed in case of persistent or recurrent leakage on fluorescein angiography and/or intraretinal fluid on optical coherence tomography. Evaluation of best-corrected visual acuity using Early Treatment of Diabetic Retinopathy Study criteria, MP-1 microperimetry, optical coherence tomography, and fluorescein angiography were performed before treatment and 1 month, 3 months, 6 months, and 1 year after treatment. Results: After a follow-up of 12 months, best-corrected visual acuity improved on average of 0.23 logarithm of the minimum angle of resolution. Mean macular sensitivity within the central 8° increased on average of 2.62 dB at 12-month postinjection. The mean number of measurement points within the central absolute scotoma reduced significantly from 12.47 before treatment to 6.27 at 1-year follow-up. An improvement of fixation stability from baseline was observed in 9 patients (60%). No treatment adverse events were evidenced. Conclusion: Improvement of macular sensitivity and fixation stability 1 year after intravitreal bevacizumab for myopic choroidal neovascularization suggest a stable and progressive macular function recovery. The mean treatment session was 1.53, with 53.3% of patients needing only a single intravitreal bevacizumab injection, supporting a potential long-lasting efficacy of intravitreal bevacizumab treatment. RETINA 30:739 –747, 2010 C horoidal neovascularization (CNV) secondary to pathologic myopia is one of the leading causes of central visual loss in the working-aged population throughout the world; it occurs in 5% to 10% of patients with high myopia. 1 Because it has been shown that vascular endothe- lium growth factor (VEGF) represents a major stim- ulator for neovascular growth in age-related macular degeneration and that it also plays an important role in promoting CNV in myopic patients, 2 the need for new pharmacologic agents that could block its action be- comes apparent. Recently, the off-label use of intravitreal bevaci- zumab (IVB) (Avastin, Genentech Inc., San Fran- 739