_____________________________________________________________________________________________________ *Corresponding author: E-mail: salehikamal88@gmail.com; Journal of Pharmaceutical Research International 26(2): 1-8, 2019; Article no.JPRI.46877 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) The Effect of Aromatherapy with Citrus aurantium on Anxiety during MRI Imaging in Patients with Spinal Disorders: A Randomized Clinical Trial Nishtman Ahani 1 , Kamal Salehi 2* , Jamal Seidi 2 , Bakhtyar Salehi 3 and Bijan Nouri 4 1 Student Research Committee, Kurdistan University of Medical Science, Sanandaj, Iran. 2 Clinical Care Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. 3 MRI Department, Imam Khomeini Hospital of Saqqez, Iran. 4 Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2019/v26i230134 Editor(s): (1) Dr. Jinyong Peng, Professor, College of Pharmacy, Dalian Medical University, Dalian, China. Reviewers: (1) Vijaya Krishnan, (PT) MGM College of Physiotherapy, Navi Mumbai, India. (2) Daniela Benedec, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania. Complete Peer review History: http://www.sdiarticle3.com/review-history/46877 Received 24 October 2018 Accepted 26 January 2019 Published 27 March 2019 ABSTRACT Objective: Anxiety is one of the most significant problems of patients during magnetic resonance imaging (MRI). Anxiety affects the quality of images, increased costs and repeating the imaging process. Aromatherapy is regarded a complementary therapy that is assumed to be highly effective in reducing anxiety. The present study aims at investigating the effect of aromatherapy with Citrus aurantium on anxiety in MRI imaging. Materials and Methods: This randomized clinical trial was done on 80 patients with spinal disorders that were randomly assigned to the intervention and control groups. In the intervention group, inhaling Citrus aurantium essential oil was conducted two minutes before entering the MRI machine and right before entering the MRI machine. As for the control group, the patients were provided with only the common cares of the medical center. Right after the imaging process, the Original Research Article