Research Article Proliferative Glomerulonephritis: Risk Factor for Hypertension in Lupus Mansour Mbengue , 1 Motula Latou Lot, 2 Seynabou Diagne, 3 and Abdou Niang 1 1 Department of Nephrology, Dalal Jamm University Hospital, Dakar, Senegal 2 Department of Nephrology, Aristide Le Dantec University Hospital, Dakar, Senegal 3 Department of Nephrology, Pikine Hospital, Dakar, Senegal Correspondence should be addressed to Mansour Mbengue; mansourmbengue92@gmail.com Received 31 December 2020; Accepted 1 April 2021; Published 15 April 2021 Academic Editor: ereza Maria Magalhães Moreira Copyright © 2021 Mansour Mbengue et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Studies report a high prevalence of hypertension in lupus, reaching up to 74%. e incidence of hypertension in SLE patients is increased with the severity of the kidney damage. is work was carried out with the objective of determining the prevalence of hypertension in lupus nephritis and to seek the existence of an association between the presence of a proliferative glomeru- lonephritis and hypertension. Patients and Methods. is was a case-control study, carried out in the nephrology department of the Aristide Le Dantec University Hospital in Dakar. All records of patients with lupus nephritis over a 10-year period, from January 01, 2007, to December 31, 2016, were included. Results. During the study period, out of 64 lupus nephritis records collected, 28 patients had hypertension, for a hospital prevalence of 43.75%. e mean age of the patients was 30.64 years ± 10.44. ere were 24 women and 4 men. e mean systolic blood pressure was 156mmHg (110–220) and the mean diastolic blood pressure was 100mmHg (80–130). e mean serum creatinine was 29.48mg/l ± 24.99. e mean proteinuria was 4.50g/ 24h ± 2.87. Hypertriglyceridemia was observed in one patient. Hypercholesterolemia was present in 3 patients. HDL levels were normalinallpatientsandelevatedLDLlevelswerenotedinall4patients.Noneofourpatientshaddiabetes.ClassIIIwasfoundin 11 cases, class IV in 14 cases, pure class V in 2 cases, and class II in 1 case. Hypertension was associated with the presence of proliferative glomerulonephritis (odds ratio, 7.45; 95% CI, 1.9 to 29.1; p � 0.002). Conclusion. Hypertension is common in lupus nephritis. e presence of a proliferative glomerulonephritis is a risk factor for the development of arterial hypertension. Screeningandadequatemanagementofhypertensionareessentialforthepreventionoftheprogressionofchronickidneydisease in lupus. 1. Introduction Several studies report a high frequency of hypertension in lupus, reaching up to 74% in some cohorts [1–4]. e in- cidence of hypertension in SLE patients is also increased with the severity of the kidney damage. Besides nephrop- athy, other factors are involved in the development of hy- pertension in lupus. ese include activation of the renin angiotensin aldosterone system (RAAS) and immune dys- regulation seen in patients with SLE. e presence of hy- pertension has several implications for the prognosis of lupus nephritis. Studies in the recent years have shown that the primary cause of death for SLE patients is no longer the autoimmune pathology itself, neither the infectious conse- quences of immunosuppressive treatments, but primarily cardiovascular pathologies [5]. Lupus is the cause of major and accelerated atheroscle- rosis, possibly through nephropathy but also through chronic inflammation and metabolic complications, immunosup- pressive treatments, and corticosteroids. A recent meta- analysis clearly confirms that SLE patients have a cardio- vascular risk almost twice that of the general population, this being much more marked for the youngest patients [6]. Hypertension is one of the important determinants of the progression of atherosclerosis in lupus. In addition, hypertensionisrecognizedasoneofthefactorscontributing Hindawi International Journal of Hypertension Volume 2021, Article ID 6691821, 4 pages https://doi.org/10.1155/2021/6691821