_____________________________________________________________________________________________________ *Corresponding author: E-mail: masuqul2003@ru.ac.bd; Asian Journal of Chemical Sciences 6(1): 1-8, 2019; Article no.AJOCS.48032 ISSN: 2456-7795 Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of N-(4- methoxybenzylidene) Isonicotinohydrazone Schiff Base Md. Sajjad Hossain 1 , Farzana Khanm Camellia 1 , Nayon Uddin 1 , Md. Kudrat-E-Zahan 1 , Laila Arjuman Banu 1 and Md. Masuqul Haque 1* 1 Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh. Authors’ contributions This work was carried out in collaboration among all authors. Authors MSH and FKC performed the experimental study, wrote the protocol and wrote the first draft of the manuscript. Authors NU and MKEZ managed the analyses of the study. Author LAB designed the study. Author MMH supervised all the work. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJOCS/2019/v6i118987 Editor(s): (1) Dr. V. Sivamurugan, PG & Research Department of Chemistry, Pachaiyappa’s College, University of Madras, Chennai, India. Reviewers: (1) Manojit Pal ,Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India. (2) Pipat Chooto, Prince of Songkla University, Thailand. Complete Peer review History: http://www.sdiarticle3.com/review-history/48032 Received 11 January 2019 Accepted 23 March 2019 Published 03 April 2019 ABSTRACT Two complexes of Cu(II) and Ni(II) with the ligand N- (4-methoxybenzylidene) isonicotinohydrazide, having the formula [M(La) 2 ] 2+ (M = Cu(II) and Ni(II)) were synthesized. The ligand was synthesized by the condensation of isonicotinic acid hydrazide (isoniazid) with 4- methoxybenzaldehyde (p- anisaldehyde). The complexes were characterized by FTIR, UV-Vis spectroscopy, molar conductivity, magnetic susceptibility and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E. coli) and gram positive Bacillus cereus (B. cereus)strains. The results indicate that all complexes consist of N and O coordination with metals has better antimicrobial activity. Original Research Article