Disease Prevention and Public Health Journal e-ISSN: 2720-9997 Vol. 16, No. 1, March 2022, pp. 70-78 http://journal2.uad.ac.id/index.php/dpphj/index ph@uad.ac.id 10.12928/dpphj.v16i1.5293 The Factor of Association of Diabetes Knowledge in Diabetes Mellitus type 2 Patients Monthida Sangruangake 1 , Ponpimon Srisuwan 2 , Piches Ruangsuksud 3 , Solikhah Solikhah 4 , Thiti Sungworawongpana 5 1,3, 5 Faculty of Nursing, Khon Kaen University, Khon Kaen, Thailand 2 Faculty of Nursing, Ratchathani University, (Udon Thani Campus), Thailand 4 Faculty of Public Health, Universitas Ahmad Dahlan, Indonesia *corresponding author; email address: solikhah@ikm.uad.ac.id ARTICLE INFO ABSTRACT Article history Received 07/12/21 Revised 18/01/22 Accepted 23/02/22 Background: T2DM is a chronic illness associated with numerous comorbidities and leads to chronic complications, resulting in high morbidity and mortality, rising health care costs. However, patients with this disease, through self-care, can significantly mitigate the risk, or delay the onset of these T2DM complications. This research aims to investigate factors along with Diabetes Knowledge. Method: A cross-sectional study was carried out among T2DM patients living in both rural and urban areas from the Central and Northeastern regions of Thailand were recruited from outpatient diabetes clinics of both community and university hospitals in both the Khon Kaen and Bangkok provinces of Thailand. Patients were sampled using a stratified sampling design where strata were based on locality (Province) -hospital size combinations. Firstly, we had translated all questionnaires from English to the local language then again back-translated simultaneously. Then, the third step was to perform psychometric testing of the DK instrument. Lastly, binary logistics mixed-effect regression was used to investigate the clustering effect of the participant’s characteristics on this study. Results: After adjusting for covariates derivate that age, KK, and smaller hospitals, higher education, monthly income, underweight and overweight, DM treatment, and smoking nor alcohol were all found to be associated with various DK. Conclusion: In the future DK measurement is likely to provide valuable insights into the epidemiology of diabetes self- management and may also be used to evaluate interventions to reduce poor self-care in T2DM patients, in turn, politically reducing the incidence of, and mortality from, type 2 diabetes mellitus complications. This is an open access article under the CC–BY-SA license. Keywords T2DM DK Instrument Diabetes mellitus Thailand 1. Introduction Diabetes mellitus (DM) and its complications in adults remain a global health problem and ranks fifth among causes of death in the world [1]. Currently, there are approximately 366 million people worldwide with diabetes, of which over 90%-95% of these have type 2 diabetes (T2DM) [2]. The burden of T2DM globally is increasing. Approximately 280 million adults are estimated to have impaired glucose tolerance, also known as "pre-diabetes". The global prevalence of T2DM among adults (aged 20–79) will be 6.4% or 285 million adults in 2010, and will reach 7.7% or 439 million adults by 2030 [3-4]. Diabetes mellitus is one of the most common chronic diseases in