_____________________________________________________________________________________________________ *Corresponding author: E-mail: osama.neuro2003@gmail.com; International Neuropsychiatric Disease Journal 6(2): 1-8, 2016; Article no.INDJ.22785 ISSN: 2321-7235, NLM ID: 101632319 SCIENCEDOMAIN international www.sciencedomain.org Epilepsy among Cerebral Palsy Children: Clinical Predictors and Frequency Osama Abdel Salam 1* , Ahmed Esmael 1 and Mohamed El-Sherif 1 1 Department of Neurology, Faculty of Medicine, Mansoura University, Mansoura 35516, Dakahlia, Egypt. Authors’ contributions This work was carried out in collaboration between all authors. Author OAS designed the study and wrote the protocol. Author AE preformed the statistical analysis. Author MES managed the literature search and wrote the first draft of the manuscript with assistance from author OAS. All authors read and approved the final manuscript. Article Information DOI: 10.9734/INDJ/2016/22785 Editor(s): (1) Zhefeng Guo, Department of Neurology, University of California, Los Angeles, USA. Reviewers: (1) Jera Kruja, University of Medicine, Tirana, Albania. (2) Antonio Diaz Negrillo, Infanta Elena Hospital, Madrid, Spain. (3) Debopam Samanta, University of Arkansas for Medical Sciences, USA. Complete Peer review History: http://sciencedomain.org/review-history/12694 Received 26 th October 2015 Accepted 1 st December 2015 Published 16 th December 2015 ABSTRACT Introduction: Epilepsy is one of the most common neurological disorder in childhood. The risk of epilepsy is highest in children with brain abnormalities, such as cerebral palsy. There are a lot of studies showing that epilepsy varies from 12-19 percent in children with CP. Objective: The objective of this study is to determine the relationship between cerebral palsy (CP) and epilepsy and how to predict development of seizures among cerebral palsy children. Subject and Methods: A prospective study included 82 patients with cerebral palsy and history of seizure. Seizure were classified according to ILAE classification, an EEG and neuro-imaging were obtained in all cases. We analyzed the incidence of different types of epilepsy in relation to different subtypes of cerebral palsy. Other factors associated with epilepsy such as age of starting first attack, neonatal seizures and familial factors were also analyzed. Results: In our study the most common risk factors were perinatal factors 40 patients (48.8%): 16 of them had epilepsy. While the less common risk factors were postnatal factors 10 patients (12.2%): 6 of them had epilepsy. The incidence of epilepsy in our sample was significantly higher Original Research Article