_____________________________________________________________________________________________________ *Corresponding author: E-mail: samiasolom@yahoo.com; British Journal of Medicine & Medical Research 19(5): 1-17, 2017; Article no.BJMMR.25943 ISSN: 2231-0614, NLM ID: 101570965 SCIENCEDOMAIN international www.sciencedomain.org The Validity of Poisoning Severity Score in Acute Carbon Monoxide Intoxicated Patients Samia S. Barghash 1* , Hala Nasser El Sherif 1 , Rawya Mohammed Salah El-Din 1 and Azza Mohammed Hassan 1 1 Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine for Girls, Al- Azhar University, Cairo, Egypt. Authors’ contributions This work was carried out in collaboration between all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/BJMMR/2017/25943 Editor(s): (1) Franciszek Burdan, Experimental Teratology Unit, Human Anatomy Department, Medical University of Lublin, Poland and Radiology Department, St. John’s Cancer Center, Poland. (2) Sinan Ince, Department of Pharmacology and Toxicology, University of Afyon Kocatepe, Turkey. (3) Salomone Di Saverio, Emergency Surgery Unit, Department of General and Transplant Surgery, S. Orsola Malpighi University Hospital, Bologna, Italy. Reviewers: (1) Ghulam Nabi, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China. (2) Lorna T. Enerva, Polytechnic University of the Philippines, Philippines. (3) Miguel A. Sogorb, Bioengineering Institute, Miguel Hernández University, Spain. Complete Peer review History: http://www.sciencedomain.org/review-history/17398 Received 27 th March 2016 Accepted 23 rd December 2016 Published 31 st December 2016 ABSTRACT Background and Objective: The poisoning severity score is a standardized and generally applicable scheme for grading the severity of poisoning. It allows a qualitative evaluation of morbidity and facilitates comparability of data. The aim of this study was to evaluate the validity of the poisoning severity score in patients with acute carbon monoxide poisoning as a result of their descriptive, laboratory, clinical data and outcome. Subjects and Methods: An observational prospective study design was used in the data collection process for eighty Co poisoned patients who presented to Poison Control Center (PCC), Ain Shams University Hospital, Egypt over six months. Patients with coronary artery disease or other known heart disease, patients with renal failure as well as smoker subjects were excluded. The patients were divided into 3 grades according to the poisoning severity score (PSS) which was applied to all patients in the present study at the emergency department. Also a group consisted of twenty apparently healthy nonsmoker volunteers (of matched age and sex) were served as a Original Research Article