Contents Volume 88 Issue 3 | JNNP March 2017 Editor Matthew C Kiernan (Australia) Deputy Editors Karen L Furie (USA) Satoshi Kuwabara (Japan) Lawrence Wong (China) Associate Editors Alan Carson (UK) Nick Ward (UK) Peter Warnke (USA) Commissioning Editor Martin Turner (UK) Web Editors Clare Caldwell Arun Krishnan Cindy Lin Steve Vucic Editors, Practical Neurology Geraint Fuller (UK) Phil Smith (UK) Editorial Office Journal of Neurology Neurosurgery & Psychiatry BMJ Publishing Group Ltd BMA House Tavistock Square London WC1H 9JR, UK T: +44 (0)20 7383 6909 F: +44 (0)20 7383 6668 E: jnnp@bmj.com Twitter: @JNNP_BMJ ISSN: 0022-3050 (print) ISSN: 1468-330X (online) Impact factor: 6.431 Disclaimer: JNNP is published by BMJ Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association. The BMJ Group grants editorial freedom to the Editor of JNNP. JNNP follows guidelines on editorial independence produced by the World Association of Medical Editors and the code on good publication practice of the Committee on Publication Ethics. JNNP is intended for medical professionals and is provided without warranty, express or implied. Statements in the journal are the responsibility of their authors and advertisers and not authors’ institutions, the BMJ Publishing Group or the BMA unless otherwise specified or determined by law. Acceptance of advertising does not imply endorsement. To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, injury or damage resulting from the use of JNNP or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. Copyright: © 2017 BMJ Publishing Group. All rights reserved; no part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without prior permission. JNNP is published by BMJ Publishing Group Ltd, typeset by Nova Techset Private Limited, Bengaluru & Chennai, India and printed in the UK on acid-free paper from sustainable forests. Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Cover image: Brain tree. Editorial commentaries 193 Active immunotherapy may delay disability in progressive MS A Haghikia, R Gold 194 Too fast: rare neuropathic pain state associated with easy activation of Na V 1.9 S B Park, M D Baker 195 Detecting dysexecutive syndrome in neurodegenerative diseases: are we using an appropriate approach and effective diagnostic tools? M Poletti, M Cavallo, M Adenzato Multiple sclerosis 196 Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis N Lizak, A Lugaresi, R Alroughani, J Lechner-Scott, M Slee, Eva Havrdova, D Horakova, M Trojano, G Izquierdo, P Duquette, M Girard, A Prat, P Grammond, R Hupperts, F Grand’Maison, P Sola, E Pucci, R Bergamaschi, C Oreja-Guevara, V V Pesch, C Ramo, D Spitaleri, G Iuliano, C Boz, F Granella, J Olascoaga, F Verheul, C Rozsa, E Cristiano, S Flechter, S Hodgkinson, M P Amato, N Deri, V Jokubaitis, T Spelman, H Butzkueven, T Kalincik, on behalf of the MSBase Study Group Movement disorders 204 Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson’s disease J Collett, M Franssen, A Meaney, D Wade, H Izadi, M Tims, C Winward, M Bogdanovic, A Farmer, H Dawes 212 Subtle motor disturbances in PREDICT-PD participants A J Noyce, A Schrag, J M Masters, J P Bestwick, G Giovannoni, A J Lees Neuro-inflammation 218 Ring-enhancing spinal cord lesions in neuromyelitis optica spectrum disorders N L Zalewski, P P Morris, B G Weinshenker, C F Lucchinetti, Y Guo, S J Pittock, K N Krecke, T J Kaufmann, D M Wingerchuk, N Kumar, E P Flanagan Neurodegeneration 226 A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment D R Roalf, M J Moberg, B I Turetsky, L Brennan, S Kabadi, D A Wolk, P J Moberg Neurogenetics 233 Familial gain-of-function Na v 1.9 mutation in a painful channelopathy C Han, Y Yang, R H te Morsche, J P H Drenth, J M Politei, S G Waxman, S D Dib-Hajj Cerebrovascular disease 241 Meta-analysis of timing of endovascular aneurysm treatment in subarachnoid haemorrhage: inconsistent results of early treatment within 1 day S Rawal, P Alcaide-Leon, R L Macdonald, G J E Rinkel, J C Victor, T Krings, M K Kapral, A Laupacis 249 Stroke paradox with SGLT-2 inhibitors: a play of chance or a viscosity-mediated reality? K P Imprialos, C Boutari, K Stavropoulos, M Doumas, A I Karagiannis Cognitive neurology 254 Assessing the dysexecutive syndrome in dementia D A Gansler, E D Huey, J J Pan, E Wasserman, J H Grafman Neuropsychiatry 262 Cognitive outcome after ventral capsule/ventral striatum stimulation for treatment-resistant major depression C S Kubu, T Brelje, M A Butters, T Deckersbach, P Malloy, P Moberg, A I Tröster, E Williamson, G H Baltuch, M T Bhati, L L Carpenter, D D Dougherty, R H Howland, A R Rezai, D A Malone Jr MORE CONTENTS This journal is a member of and subscribes to the principles of the Committee on Publication Ethics http://publicationethics.org/ This article has been made freely available online under the BMJ Journals Open Access scheme. See http://jnnp.bmj.com/site/about/guidelines.xhtml#open This article has been chosen by the Editor to be of special interest or importance and is freely available online. This article has been chosen in conjunction with the BMJ Patient Forum to be of particular interest to patients and is freely available online. The article is part of the Impact Commentaries series on December 16, 2021 by guest. Protected by copyright. http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as on 1 March 2017. Downloaded from