RESEARCH AND EDUCATION ISSN: 2181-3191 VOLUME 1 | ISSUE 9 | 2022 Scientific Journal Impact Factor 2022: 4.628 http://sjifactor.com/passport.php?id=22258 https://t.me/ResearchEdu_Journal Multidisciplinary Scientific Journal December, 2022 88 INFLUENCE OF ORAL MICROBIOTA ON THE DEVELOPMENT OF INFLAMMATORY AND SOMATIC DISEASES Nazokat Muratjonovna Alieva, Assistant Professor, Department of Propaedeutic of Ortopaedic Dentistry alievanazokat1979@gmail.com Mohinur Azizovna Tolipova Assistant Professor, Department of Propaedeutic of Ortopaedic Dentistry mokhinurazizovna@gmail.com Malika Ulmasovna Ochilova Assistant, Department of Propaedeutic of Ortopaedic Dentistry ochilova.m@gmail.com ANNOTATION The review presents the modern concept of the oral microbioma, its species diversity, the properties of microbial associations and their effect on the immunobiological resistance of the organism, the development of chronic inflammation and the two leading infectious and inflammatory diseases, dental caries and periodontal diseases. Briefly summarized information about the presence and nature of the relationship between the composition of periodontal microorganisms and concomitant somatic diseases: in atherosclerotic plaques in cardiovascular diseases, with pathology of the gastrointestinal tract, respiratory system and other organs and systems. Keywords: microbiology, oral cavity, somatic diseases. The connection between infections of the dentition and diseases in other anatomical areas of the body has been known for more than a hundred years, which contributes to the search for common etiological and pathogenetic factors of these disorders. But only with the advent of molecular genetic methods of research did the study of the biology of microorganisms (microbiome) really begin as one of the leading triggers for the development and progression of inflammatory diseases of the dental system. This is very important to take into account in the treatment of diseases of hard tissues of the tooth, periodontium and the prevention of inflammatory complications after relatively clean operations in the oral cavity.