https://journals.insparagonsociety.org/index.php/aritmetika 1 A Bioinformatics Research of Active Compounds Curcuma xanthorriza in Arthritis Disease Eko Nevriansyah, Arinda Frissherly a , Anisa Qisti Mathriul b , Ulfa Niesya Putri c , Silvi Handri d Magister Programme of Biochemistry, Postgradute, Universitas De La Salle, Philippines a Department of Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Padang, Jl. Prof. Dr. Hamka, Air Tawar Barat, Padang Utara, West Sumatera, Indonesian b Department of Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Gedung Pascasarjana Kampus UI Depok, Pondok Cina, Kecamatan Beji, Kota Depok, West Jawa, Indonesian c Department of Department of Public Health, Faculty of Medicine, Universitas Andalas, Limau Manis, Pauh, Padang City, West Sumatra, Indonesian d Magister Programme of Educational Chemistry, Postgraduate, Faculty of Mathematics and Natural Science, Universitas Negeri Padang, Jl. Prof. Dr. Hamka, Air Tawar Barat, Padang Utara, West Sumatera, Indonesian *Coresponding email: afrissherly@gmail.com ABSTRACT Curcuma xanthorriza roxb. or commonly known as ginger is a plant that grows in the tropics which is known as a million benefits plant, one of which is for the treatment of Arthritis. The main active compounds that act as anti-inflammatory which refer to arthritis are curcumin and demethoxycurcumin. The purpose of this study was to analyze the active compounds contained in ginger which play an important role in the treatment of arthritis. Bioinformatics analysis was carried out using the ChemOffice 2016 software using the molecular mechanics method. The 2-dimensional structure analysis uses the ChemDraw program, while the 3-dimensional structure analysis uses the Chem3D program. From the data optimization results using the molecular mechanics method, the following results are obtained: The total energy produced in the compounds curcumin, d-camphor, demethoxycurcumin, p-tolymethilcarbinol, starch, respectively 17.4573 kcal / mol; 29,2006 kcal / mol; 13.8948 kcal / mol; -0.6574 kcal / mol; and 29,6089 kcal / mol. Based on the research data obtained, it can be concluded that the active compounds curcumin and demethoxycurcumin are compounds that act as anti-inflammatory triggers for arthritis. It is proven that the results of the MM2 method are in accordance with the related theory. Keyword: curcuma, anti-inflammatory, molecular mechanics, curcumin, demethoxycurcumin.. Keywords: Anti-inflammatory; Curcuma; Curcumin, Demethoxycurcumin; Molecular mechanics 1. INTRODUCTION Temulawak is a type of medicinal plant that is very well known in Indonesia or other tropical areas which is usually used as a spice in the kitchen. In biology, ginger is a family Zingiberaceae and one of its genera is Curcuma [1] [2]. Curcuma xanthorrizha (temulawak) is a medicinal plant that is thought to be able to prevent joint pain, known as arthritis [3-5]. There are 3 main ingredients in ginger including starch, curcuminoids and essential oils [6]. Chemical content that is directly related to joint pain is curcuminoids in which there are 3 active compounds, namely curcumin, demethoxycurcumin and bisdemethoxycurcumin [7-9]. Inflammation is a body's protective response to reduce and eliminate triggers for an injury or infection that usually harms the body [23]. Not only as anti-inflammatory alone, other functions of curcuma are also used as antioxidants [10-13], anticancer [14-16], and others. Testing the content of Vol 01 2022, pp 26-33 e-ISSN: XXXX-XXXX DOI: https://doi.org/10.54482/ARITMETIKA/