Journal of Biomedical and Pharmaceutical Research Available Online at www.jbpr.in CODEN: - JBPRAU (Source: - American Chemical Society) PubMed (National Library of Medicine): ID: (101671502) Review Article Volume 8, Issue 5: September-October: 2019, 13-20 ISSN (Online): 2279-0594 ISSN (Print): 2589-8752 13 | Page PHARMACOLOGICAL NEUROPROTECTIVE EFFICACY OF ESSENTIAL OILS (EO) BASED AROMATHERAPY: AN INSIGHT Arushi Pant 1 , Shriya Agarwal 1 , Kanupriya Jha 1 , Manisha Singh 1* 1 Department of Biotechnology, Jaypee Institute of Information Technology, JIIT, Noida, U.P., India. Article Info: Received 10 August 2019; Accepted 16 September. 2019 DOI: https://doi.org/10.32553/jbpr.v8i5.646 Corresponding author: Manisha Singh Conflict of interest statement: No conflict of interest ABSTRACT: Aromatherapy or Essential oil therapy is attributed towards the field of conventional, alternative or complementary therapies which requires essential oils and other aromatic plant compounds. Essential oils (EOs) belong to the class of highly volatile compounds which, due to their higher concentrated natural constituents acquire unique properties and hence, are being used for its wide range of therapeutic health benefits. Their benefits widely range from being a potential antimicrobial, antidepressant, antiviral and antiseptic agents to the elevator of many CNS related behaviours like - anxiety, stress, wisdom, memory, attention, relaxation, sedation, and sleep. Furthermore, the effects on mood, pain, and perception too are being influenced by the use of essential oils. It also helps in the treatment of epilepsy, stress, dementia by giving calming and soothing effects to the nerve cells and is also effective against dementia and on the treatment of Alzheimer’s disease. Keywords: Alzheimer’s disease, Analgesic Action, dementia, epilepsy, aromatherapy. INTRODUCTION Essential oils (EO) are considered as the most integral part of the tradition from the ancient civilization till present as it indistinguishably intertwines the religious and the therapeutic roles[1]. Few of the practices are still in use, for instance, the junipers are burnt in Tibetan temples as it is considered as a purification ceremony and, in the west, frankincense is used by the Roman Catholics during their masses[2].The production of EO by the alchemists can be traced back to at least 2000 years, which was done through the simple extraction method and led to a major step towards the later herbal development which targeted the health, endurance, and spiritual knowledge. The Chinese traditional medicinal (CTM) system quoted that the essential oils are considered as the medicine which not only benefits the health but governs the consciousness of the human beings too[3]. Similarly, according to the Ayurvedic practices, EOs enhances the life, longevity and brightens the intellect levels in living beings[4]. Essential Oils are low molecular weight hydrophobic liquids, extracted from plants and are rich in bioactive and aromatic phytocompounds exhibiting various therapeutic properties.EOs are the class of highly volatile compounds which are having a high concentration of natural constituents, derived from plants for its unique properties[5].The essential oils which are extracted from the plants, exhibits various characteristics i.e. odour characteristics, healing power and various therapeutic properties thereby use for wide range of health benefits[6].Numerous chemical compounds are present in the essential oils and each of its compounds possesses unique and therapeutic properties ranging from anti-microbial, antidepressant, antiviral and antiseptic agents to various other properties which make it an important candidate in eliminating various health- related disorder[7]. Even a small quantity of these oils can cure various common health challenges specifically health-related disorders, aiming at restoring the comfort, peace of mind, healthy skin and help in maintaining a healthy functional body[8]. For example, Thyme[9], Sage[10], Eucalyptus Oil[11] are used as antiseptics. The German chamomile[12] and lavender[13] are used as anti-inflammation oils which gives a soothing effect to the skin. The geranium[14] and Rose oil[15] are used as granulation stimulating or as