Journal of Pharmaceutical Negative Results ¦ Volume 14 ¦ Regular Issue 03 ¦ 2023 3765 Facial Paralysis Can Be Treated With Computer Application, A Knowledge-Based System Dr. Imran Qazi 1 , Dr. Efat Jahan Moname 2 , Divya Pathak 3 , Usama Rauf Khattak 4 , Maryam Qudsia 5 , Dr Naveed Ahmad 6 1 Khyber Teaching Hospital (KTH) Peshawar, Pakistan: Email: drimranqaziuae@gmail.com 2 MAG Osmani Medical College, Sylhet, Bangladesh. Email: efatjahan15@gmail.com 3 Department of Pharmacy, IIMT College Medical Sciences, IIMT University, India 4 Electronics Engineering Department, University of Engineering and Technology Taxila, Pakistan. Email: raufusama2000@gmail.com 5 Department of Radiology, Shifa Tameer e Millat University, Islamabad, Pakistan. Email: qudsiastic567@gmail.com Lecturer Sargodha Medical College E mail: docnaveed711504@gmail.com DOI: 10.47750/pnr.2023.14.03.472 This research paper highlights the significance of user-centric design in developing a knowledge-based system for the rehabilitation of facial paralysis, with a focus on Bell's palsy. The paper emphasizes the importance of involving both end- users and professionals in the design process and iterating through all phases until the evaluation findings are satisfactory. The paper also discusses the characteristics of Bell's palsy, its prevalence, and the challenges in diagnosing and rehabilitating subtle facial deviations. The paper proposes a user-centered knowledge-based system to aid in the rehabilitation of Bell's palsy and other facial paralysis conditions. The paper reviews the existing efforts made towards treating facial paralysis and details the user-centered design process that informed the proposal's creation. The paper concludes with a discussion of the implications of this research and future research directions. Overall, this paper provides insights into the user-centered design approach for developing technology-based solutions for the rehabilitation of facial paralysis, which could help improve the quality of life for those who have suffered from these conditions. Keywords: Paralysis of the face, user-centered design, and knowledge-based systems INTRODUCTION: In user-centric design, every facet of the user's experience is considered through developing strategies based on an in-depth knowledge of users, activities, and contexts. It is crucial to have both the end user and a team of professionals involved in the design process while creating and evaluating a product. All phases are repeated in each iteration until the evaluation findings are satisfactory: comprehending and understanding the context of usage; specifying user needs; designing solutions; evaluating the project against the requirements. Acute idiopathic peripheral nerve palsy, also known as Bell's palsy, affects the facial nerve, affecting all facial muscles (Cervantes et al., 2019; Derakhshan et al., 2023). Subtle facial deviations require the expertise of trained professionals for diagnosis and correction because they cannot always be seen by the unaided eye. Bell's palsy affects between 15 and 30 boys and females per 100,000 yearly, regardless of age group. Face nerve paralysis is characterized by abrupt onset and loss of motor and sensory function in the facial nerve's periphery. The primary objective of rehabilitation is to restore face symmetry by eliminating swelling, preventing scar adhesions, restoring standard mandibular opening and lateralization, and re-education the muscles (Shokri et al., 2023; Stabile-Del Vecchio & Morales-Chávez, 2020). We are interested in helping those who have suffered facial paralysis by developing a knowledge-based system that is user-centered in its approach to rehabilitation. The remaining parts of the paper are organized as follows: We begin by discussing efforts made toward applications that aid in treating facial paralysis. The phases of the user-centered design process that informed the proposal's creation for the proposed application are then detailed. The conclusions and directions for further research are then discussed (Ferllini et al., 2020).