Indian Journal of Forensic Medicine & Toxicology, October-December 2020, Vol. 14, No. 4 7335 Indices Changes of Central Hemodynamics at Carry Out Anesthesia with Keeping Independent Breathing at Children Gulchekhra Ashurova 1 , Nigora Zokirova 2 , Talat Agzamkhodjayev 3 , Anvar Yusupov 4 , Ikhtiyor Mamatqulov 5 1 Research Scholar, MD, Teaching Assistant, Department of Anesthesiology and Intensive Care, Pediatric Anesthesiology and Intensive Care, Tashkent Pediatric Medical Institute, 223 Bogishamol Str., Yunusobod district, Tashkent, Uzbekistan, 2 Research Scholar, Teaching Assistant, Department of Anesthesiology and Intensive Care, Pediatric Anesthesiology and Intensive Care, Tashkent Pediatric Medical Institute, 223 Bogishamol Str., Yunusobod district, Tashkent, Uzbekistan, 3 Doctor of Science, MD, Professor, Department of Anesthesiology and Intensive Care, Pediatric Anesthesiology and Intensive Care, Tashkent Pediatric Medical Institute, 223 Bogishamol Str., Yunusobod District, Tashkent, Uzbekistan, 4 PhD, MD, Docent, Department of Anesthesiology and Intensive Care, Pediatric Anesthesiology and Intensive Care, Tashkent Pediatric Medical Institute, 223 Bogishamol Str., Yunusobod district, Tashkent, Uzbekistan, 5 Research Scholar, MD, Teaching assistant, Department of Anesthesiology and Intensive Care, Pediatric Anesthesiology and Intensive Care, Tashkent Pediatric Medical Institute, 223 Bogishamol Str., Yunusobod District, Tashkent, Uzbekistan Abstract Introduction: The aim of study was to research hemodynamic shifts in conditions of carry out combined anesthesia on the base of isofurane with preservation of spontaneous breathing at small surgical operations in children. Materials and Method: The research was carried out at 44 sick children at the age from 3 to 14 years with inguinal and inguinal hernias (41,7 %), hydrocele was (19,4 %) section of abscesses and suppurations were (38,9%). The duration of anesthesia beneft at 58,3 % patients was from 30 to 40 minutes, at 40,66 % it was about 60 minutes. Results: The clinical monitoring was performed with study AP, HR and oxygen. For objective evaluation of cardiovascular functional condition, the echocardiography way was use. The frst group patients were introduced intravenously the ketamine solution in doze 3 mgr/kg of body weight, propofole in dose 2 mgr/ kg of body weight and izofurane up to 3 ob % in 30-40 minutes after premedication. The second group patients were introduced intravenously the ketamine solution in dose 4-5 mgr/body weight and sibazone in dose 0,4 mgr/kg. Conclusion: Complex clinical study and taken results of hemodynamic parameters showed the efciency of carried out anesthesia with safety of independent breathing at small surgical operations at children. Keywords: Combined ànesthesia, small surgical operations, propofole, ketamine, sibazone, izofurane. Introduction Any operation, even small surgical intervention 2 or diagnostic manipulations are multicomponent stress which may be incompatible 3 with the life of many people 5 . The small surgical operations are more often performed in conditions of general anesthesia at children. The given necessity was proved by physiological peculiarities of child’s organism, keeping safety of psychoemotial sphere, age features and severity of trauma. But these drugs in recommended doses often give the series negative efects including: suppression of independent breathing, and, the reducing amount of dose leads to non-adequate anesthesia 6 . The choice of anesthetics or their combinations depended on patient’s