JPET #99168 1 Metalloproteinase inhibitor counters high energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in sub-acute heart failure Nazareno Paolocci, Barbara Tavazzi, Roberto Biondi, Yehezkiel A. Gluzband, Angela Maria Amorini, Carlo G. Tocchetti, Mehrdad Hejazi, Patrizio M. Caturegli, Jan Kajstura, Giuseppe Lazzarino, David A. Kass Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions; Baltimore, MD (NP,CGT, DAK); Department of Clinical Medicine, Section of General Pathology, University of Perugia, Perugia, Italy (NP, RB); Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Rome, Italy (BT); Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute of Aging, Baltimore, MD (YAG); Department of Chemical Sciences, Laboratory of Biochemistry, University of Catania, Catania, Italy (AMA, GL); Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD (MH, PMC); Department of Medicine, New York Medical College, Vahalla, New York (JK). JPET Fast Forward. Published on January 25, 2006 as DOI:10.1124/jpet.105.099168 Copyright 2006 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on January 25, 2006 as DOI: 10.1124/jpet.105.099168 at ASPET Journals on December 12, 2021 jpet.aspetjournals.org Downloaded from