Citaton: Bansal P, Sharma V, Panwar A, et al. Computatonal Docking Study of the Phytochemical Consttuent, Silybin (Silybum marianum) against SARS-CoV-2 Omicron Variant Spike Glycoprotein: An In-silico Approach. J Pure Appl Microbiol. 2023;17(1):385- 394. doi: 10.22207/JPAM.17.1.29 © The Author(s) 2023. Open Access. This artcle is distributed under the terms of the Creatve Commons Atributon 4.0 Internatonal License which permits unrestricted use, sharing, distributon, and reproducton in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creatve Commons license, and indicate if changes were made. Bansal et al. | Artcle 8395 J Pure Appl Microbiol. 2023;17(1):385-394. doi: 10.22207/JPAM.17.1.29 Received: 30 December 2022 | Accepted: 19 January 2023 Published Online: 01 March 2023 RESEARCH ARTICLE OPEN ACCESS www.microbiologyjournal.org 385 Journal of Pure and Applied Microbiology P-ISSN: 0973-7510; E-ISSN: 2581-690X *Correspondence: anibiotech18@gmail.com; kdhama@redifmail.com Computatonal Docking Study of the Phytochemical Consttuent, Silybin (Silybum marianum) against SARS-CoV-2 Omicron Variant Spike Glycoprotein: An In-silico Approach Poonam Bansal 1 , Varruchi Sharma 2 , Anil Panwar 3 , Raman Kumar 4 , Aanchal Sharma 5 , Seema Ramniwas 5 , Abhijit Dey 6 , Deepak Chandran 7 , Kuldeep Dhama 8 * and Anil K Sharma 1 * 1 Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana Ambala, Haryana, India. 2 Department of Biotechnology & Bioinformatcs, Sri Guru Gobind Singh College Sector 26, Chandigarh, India. 3 Department of Bioinformatcs and Computatonal Biology, College of Biotechnology, CCS Haryana Agricultural University, Hisar, Haryana, India. 4 Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana , India. 5 University Centre for Research and Development, University Insttute of Biotechnology Chandigarh University, Gharuan, Mohali, India. 6 Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, West Bengal, India. 7 Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu, India. 8 Division of Pathology, ICAR-Indian Veterinary Research Insttute, Izatnagar, Utar Pradesh, India.