Copyright © 2019 Abdelhamid, G. S. M., Gómez-Benito, J., & Guilera, G Mail: gomaa.Abdelhamid@ub.edu Gomaa S.M. Abdelhamid, Juana Gómez-Benito, & Georgina Guilera Institute of Neurosciences, University of Barcelona, Barcelona (Spain) Schizophrenia is a chronic psychotic disorder characterized by many symptoms such as disorganized speech, grossly disorganized or catatonic behavior, depression, paranoid delusions, and auditory hallucinations (Wu et al., 2018). The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is used for measuring functional outcomes (Üstün et al., 2010). The current study aimed to identify the most common response pattern in each domain of the WHODAS 2.0 in persons with schizophrenia. Background Methods Results Discussion The most common pattern in each domain of the WHODAS 2.0 is represented by not having any disability. However, percentages of persons showing this pattern substantially vary from domain to domain: 60-70% in Mobility and Self-care or 10-20% in Participation in society, Getting along and Cognition. This suggest that is very frequent to adequately perform in Mobility and Self- care while having problems in Participation in society, Getting along and Cognition. In all domains of the WHODAS 2.0, the common response pattern consisted in scoring 1 in all the items. This pattern corresponds to not having any difficulty in doing the activities; for instance, the most common response pattern for Cognition was “111111” which means not having any difficulty in any cognition item. In addition, findings indicated that most persons with schizophrenia did not show any impairment in Self-care (69.9%) and Mobility (62.7%). Furthermore, a third of persons with schizophrenia did not show disability in the Life activities domain (Fig 1). According to the above results, the sample was dichotomized into two groups: common pattern (i.e., without difficulty) vs. non-common pattern (i.e., having difficulty ranging from at least mild to extreme or cannot do the activity). These two subgroups were compared using many clinical and functioning variables. Significant clinical differences between the two subgroups in the most domains of the WHODAS 2.0 was evident (Fig 2). The sample consisted of 352 persons with schizophrenia, according to DSM-IV-TR criteria, recruited through 40 outpatient psychiatric clinics across Spain. The complete interviewer-administered version of the WHODAS 2.0 was administered, comprising 36 items distributed across six domains: Cognition, Mobility, Self-care, Getting along, Life activities, and Participation in society. Items can be scored on a five-point scale ranging from 1 (no difficulty) to 5 (extreme difficulty/cannot do).We administered also:  The Screen for Cognitive Impairment in Psychiatry (SCIP-S)  Hamilton Rating Scale for Depression (HAM- D)  Positive and Negative Symptom Scale (PANSS)  Clinical Global Impression-Severity scale (CGI-S)  The Social and Occupational Functioning Assessment Scale (SOFAS)  The EuroQoL-5D questionnaire (EQ-5D) 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D3: Self-care Common pattern (not having any disability) D3: Self-care (Having any disability) 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D4: Getting along Common pattern (not having any disability) D4: Getting along (Having any disability) 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D5: Life activities Common pattern (not having any disability) D5: Life activities (Having any disability) 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D2: Mobility Common pattern (not having any disability) D2: Mobility (Having any disability) 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D6: Participation in society Common pattern (not having any disability) D6: Participation in society (Having any disability) 0 10 20 30 40 50 60 70 80 90 Self-care Mobility Life activities worked or students Life activities Getting along Cognition Participation in society Percentage, % Common pattern (not having any disability) Having any disability Fig 1. Percentage of patients with schizophrenia with and without disability in the domains of the WHODAS 2.0 Fig 2. Comparison between those persons with and without disability in the domains of the WHODAS 2.0 The most common response patterns to the World Health Organization Disability Assessment Schedule in persons with schizophrenia XVI European Congress of Psychology, July 2-5 2019 Moscow, Russia 0 10 20 30 40 50 60 70 80 SCIP-S PANSS HAM-D SOFAS CGI-S EQ-5D Mean score D1: Cognition Common pattern (not having any disability) D1: Cognition (Having any disability) References 1. Üstün, T.B., Chatterji, S., Kostanjsek, N., Rehm, J., Kennedy, C., Epping-Jordan, J., Saxena, S., von Korff, M., Pull, C., WHO/NIH Joint Project, 2010. Developing the World Health Organization Disability Assessment Schedule 2.0. Bull. World Health Organ. 88, 815–823. 2. Wu, Y., Kang, R., Yan, Y., Gao, K., Li, Z., Jiang, J., … Xia, L. (2018). Epidemiology of schizophrenia and risk factors of schizophrenia-associated aggression from 2011 to 2015. Journal of International Medical Research, 46(10), 4039–4049.