Original Article Pediatric Dentistry, Cariology, Dental Materials Title: Preventive effects of matrix-metalloproteinase inhibitors on dental erosion Running title: Matrix-metalloproteinase inhibitors on dental erosion Mine Koruyucu 1 , Ceren İlisulu 2 , Fahrettin Sarcan 3 , Furkan Kuruoglu 4 , Ayşe Erol 5 , Figen Seymen 6 1 Assoc Prof. Dr, Istanbul University, Faculty of Dentistry, Department of Pedodontics, Istanbul, Turkey, mine.yildirim@istanbul.edu.tr ORCID:https://orcid.org/0000-0002-2077-5095 2 Pediatric Dentist, Private Practice, Istanbul, Turkey, cerenilisulu@gmail.com, ORCID:https://orcid.org/ 0000-0003-3679-4001 3 Research Assistant, Istanbul University, Faculty of Science, Department of Physics, Istanbul, Turkey, fahrettin.sarcan@istanbul.edu.tr, ORCID:https://orcid.org/ 0000-0002-8860- 4321 4 Research Assistant, Istanbul University, Faculty of Science, Department of Physics, Istanbul, Turkey, furkan.kuruoglu@istanbul.edu.tr, ORCID: https://orcid.org/ 0000-0002- 5314-4441 5 Professor Dr, Istanbul University, Faculty of Science, Department of Physics, Istanbul, Turkey, ayseerol@istanbul.edu.tr, ORCID: https://orcid.org/ 0000-0003-4196-1791 6 Professor Dr, Istanbul University, Faculty of Dentistry, Department of Pedodontics, Istanbul, Turkey, fseymen@istanbul.edu.tr, ORCID: https://orcid.org/ 0000-0001-7010-2035 Corresponding author: Assoc. Prof. Dr. Mine KORUYUCU Istanbul University, Faculty of Dentistry Department of Pedodontics Istanbul/TURKEY Tel: 00905327746488 e-mail: mine.yildirim@istanbul.edu.tr, minekoruyucu@gmail.com Funding: This project was supported by the Research Fund of the Istanbul University (Project No: NAP-2017-27234).