CASE REPORT Reversal of retinal pigment epithelial detachment after cessation of topical travoprost therapy Venkataramana Kalikivayi . Jerry Joseph . Blessy Thankom Mathews . Rajkumar Maheswari . Satyajit Mulanjur Vadakara . Sajeev Cherian Jacob Received: 16 February 2017 / Accepted: 16 September 2017 Ó Springer Science+Business Media B.V. 2018 Abstract Purpose To report the rare incidence of retinal pigment epithelial detachment (RPED) followed by topical travoprost therapy and its subsequent reattach- ment after cessation of the drug. Methods A 60-year-old male presented with gradual loss of vision in both eyes and distorted images in right eye. He gave a history of visiting an ophthalmologist a week ago for a routine eye examination. His previous reports revealed best-corrected visual acuity (BCVA) of 6/6, N6 in both eyes with raised intraocular pressures. A diagnosis of primary open-angle glau- coma was made and prescribed topical travoprost 0.004% eye drops. This patient’s subsequent visit with diagnosis and treatment is mentioned in this case report. Results On examination, his BCVA was found to be 6/36, N12 and 6/6, N6 in right and left eyes, respectively. Optical coherence tomography (OCT) macular scan revealed RPED involving fovea in the right eye and inferotemporal to fovea in the left eye. Patient was advised to discontinue topical travoprost and started brinzolamide 1% eye drops. Ten-day follow-up visit revealed partially resolved RPED by OCT with 6/9 and 6/6 visual acuity in the right and left eyes, respectively. After 1 month, reversal of RPED was noted in OCT with 6/6 vision in both eyes. Conclusion Hence, clinicians should be aware of this rare incidence of RPED followed by travoprost therapy. First case of RPED following travoprost therapy and complete reattachment upon withdrawal is reported here in this case report. Keywords Retinal pigment epithelial detachment Á Travoprost Á Prostaglandin analogues Á Intraocular pressure Purpose To report the rare case of retinal pigment epithelial detachment followed by topical travoprost therapy and also to state its subsequent reattachment after with- drawal of the travoprost. Methods Retinal pigment epithelial detachments (RPEDs) are characterized by serous detachment and elevation of the retinal pigment epithelium (RPE) [1, 2] which is a predominant feature of many chorio-retinal diseases. V. Kalikivayi (&) Ahalia School of Optometry, Ahalia Foundation Eye Hospital, Kozhipara Post, Palakkad, Kerala, India e-mail: kalikivayi@yahoo.com J. Joseph Á B. T. Mathews Á R. Maheswari Á S. M. Vadakara Á S. C. Jacob Ahalia Foundation Eye Hospital, Kozhipara Post, Palakkad, Kerala, India 123 Int Ophthalmol https://doi.org/10.1007/s10792-017-0711-3