Accepted Manuscript Development of novel pH–responsive dual crosslinked hydrogel beads based on Portulaca oleracea polysaccharide-alginate-borax for colon specific delivery of 5- fluorouracil Geet P. Asnani, Jagan Bahekar, Chandrakant R. Kokare PII: S1773-2247(18)30903-1 DOI: 10.1016/j.jddst.2018.09.023 Reference: JDDST 784 To appear in: Journal of Drug Delivery Science and Technology Received Date: 11 August 2018 Revised Date: 19 September 2018 Accepted Date: 25 September 2018 Please cite this article as: G.P. Asnani, J. Bahekar, C.R. Kokare, Development of novel pH–responsive dual crosslinked hydrogel beads based on Portulaca oleracea polysaccharide-alginate-borax for colon specific delivery of 5-fluorouracil, Journal of Drug Delivery Science and Technology (2018), doi: https:// doi.org/10.1016/j.jddst.2018.09.023. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.