Accepted Manuscript Title: Chitosan microparticles embedded with multi-responsive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene-glycol dimetacrylate)-based hydrogel nanoparticles as a new carrier for delivery of hydrophobic drugs Authors: J´ essica de Matos Fonseca, Simone de F´ atima Medeiros, Gizelda Maria Alves, Danilo Martins dos Santos, S´ ergio Paulo Campana-Filho, Amilton Martins dos Santos PII: S0927-7765(18)30824-5 DOI: https://doi.org/10.1016/j.colsurfb.2018.11.042 Reference: COLSUB 9807 To appear in: Colloids and Surfaces B: Biointerfaces Received date: 12 July 2018 Revised date: 3 November 2018 Accepted date: 19 November 2018 Please cite this article as: de Matos Fonseca J, de F´ atima Medeiros S, Alves GM, dos Santos DM, Campana-Filho SP, dos Santos AM, Chitosan microparticles embedded with multi-responsive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene-glycol dimetacrylate)-based hydrogel nanoparticles as a new carrier for delivery of hydrophobic drugs, Colloids and Surfaces B: Biointerfaces (2018), https://doi.org/10.1016/j.colsurfb.2018.11.042 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.