S1 Supporting Information In vivo Biosynthesis of Tyrosine Analogs and their Concurrent Incorporation in a Residue-specific Manner for Enzyme Engineering Yumi Won, 1# Hyunwoo Jeon, 1# Amol D. Pagar, 1 Mahesh D. Patil, 1 Saravanan P. Nadarajan, 1 Dillon T. Flood, 2 Philip E. Dawson 2 and Hyungdon Yun 1 * 1 Department of Systems Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea. 2 Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA # Yumi Won and Hyunwoo Jeon contributed equally *Corresponding author: Hyungdon Yun, Department of Systems Biotechnology, Konkuk University, 120 Neungdong- ro, Gwangjin-gu, Seoul, 05029, Korea. E-mail: hyungdon@konkuk.ac.kr Electronic Supplementary Material (ESI) for ChemComm. This journal is © The Royal Society of Chemistry 2019