Abstract This review was conducted with the objective of determining candidate gene (CAPN1 and DGAT1) polymorphism potential on meat quality. Meat tenderness and marbling are the most economically important problem in the beef industry. Genetics and feed management are global problems that adversely affect animal meat quality and the economics of meat production in every country and cause huge financial losses. From the genetic perspective, some studies revealed that meat tenderness is highly associated with CAPN1 gene polymorphism, bringing about an amino acid replacement glycine to alanine (Gly316Ala) and Isoleucine to Valine (Ile/Val) in the identified genetic marker CAPN1-316 and CAPN530 respectively and meat marbling associated with DGAT1 gene polymorphism resulting in Lysine (K) to Alanine (A) amino acid change at location 232 K232A. Today meat tenderness and marbling attributes are determined only after an animal gets slaughter and also by using some phenotypic parameter estimations. However, there are many disadvantages associated with such beef animal selection, lengthy, costly, and labour-intensive. Therefore, alternative, live animal meat quality determination like marker-assisted selection methods is promising options. The development of molecular markers and techniques like PCR panel and sequencing will be used to identify the right live animal meat quality. Keywords: Marbling; Tenderness; Candidate gene Introducton In several parts of the developed and developing world, livestock producton is one of the principal means of achieving improved living standards. Livestock plays a critcal role in both the natonal economies and the livelihoods of rural communites in sub-Saharan African countries [1,2]. In Africa, Ethiopia has the largest livestock and ranks 5th in the world. The agro-climate of the country is ideal for livestock producton and the agricultural sample survey report (CSA, 2016/17) shows that about 59.5 million livestock, 60.90 million livestock, sheep and goats, 2.16 million horses, 8.44 donkeys, 0.41 million mules, and 1.21 million camels play a major role in the country's food and agriculture. In addition, livestock is the source of protein, fuel and, in general, animal products and by-products. Several urban and peri-urban farms are currently major suppliers to consumers of meat and milk products [3-6]. However, a number of factors restrict the productivity of this field, such as poor genetics, shortages of feed, water, treatment and prevention of diseases, and poor housing systems, resulting in low production and low reproductive efficiency. Determining the allelic and genotypic distribution of markers correlated with economically significant characteristics can be a powerful method from a genetic perspective to acquire immediate information to select the productive potential of breeds and populations of livestock [7]. Determination of functional differences such as missense variants and variants in indigenous cattle within upstream and downstream gene regions will enable these variants to be evaluated for their effects on complex traits [8-11]. Meat quality is the primary concern of the livestock industry and the needs of consumers, with appearance, juiciness, flavor, marbling, and tenderness being some of the most important sensory characteristics of meats [12]. Marbling and tenderness of meat are significant quality traits that are often used as a measure of beef products that are fresh and hygienic. Multiple genes are improved by meat tenderness and fatness, which are economically essential characteristics in breeding programs. For breeders and buyers, the selection of animals that have higher meat quality and composition is of great importance. The Diacyl-Glycerol Acyltransferase-1 gene (DGAT1), has 17 exons and mapped on chromosome 14 encodes an enzyme which involved in the conversion of carbohydrates into fat and of maintaining them in fat depots and expressed in many tissues and mammary glands, especially in adipose and epithelial tissues, with the highest levels in the gut [13]. The DGAT1 gene has also effects on the energy balance of the body and metabolic functions of the blood have also been reported. Previously researchers reported that the dinucleotide variant in Research Article iMedPub Journals www.imedpub.com Journal of Animal Sciences and Livestock Production ISSN 2577-0594 Vol.5 No.6:002 2021 © Copyright iMedPub | This article is available from: https://www.imedpub.com/animal-sciences-and-livestock-production/ 1 The Infuence of CAPN1 and DGAT1 Genes Polymorphism and Meat Quality Dejenie Mengistie 1* , Tesfaye Sisay Tessema 2 , Kwan Suk Kim 3 , Hailu Dadi 4 , and Genet Zewdie 4 1 Department of Agricultural Biotechnology, National Agricultural Biotechnology Research Center, Holeta, Ethiopia 2 Department of Agricultural Biotechnology, Addis Ababa University Institute of Biotechnology, Addis Ababa, Ethiopia 3 Department of Livestock Production, Chungbuk National University, Cheongju, South Korea 4 Department of Agricultural Biotechnology, Ethiopian Biotechnology Institute, Addis Ababa, Ethiopia * Corresponding author: Dejenie Mengiste, Department of Agricultural Biotechnology, Natonal Agricultural Biotechnology Research Center, Holeta, Ethiopia; E-mail: dejeniebiot2006@gmail.com Received date: October 04, 2021; Accepted date: October11, 2021; Published date: October 25, 2021 Citation: Mengistie D, Tessema TS, Kim KS, Dadi H, Zewdie G (2021) The Influence of CAPN1 and DGAT1 Genes Polymorphism and Meat Quality. J Anim Sci Livest Prod Vol.5 No.6:002.