_____________________________________________________________________________________________________ *Corresponding author: E-mail: ikemesitpeter@gmail.com; Asian J. Biochem. Gen. Mol. Biol., vol. 13, no. 1, pp. 30-36, 2023 Asian Journal of Biochemistry, Genetics and Molecular Biology Volume 13, Issue 1, Page 30-36, 2023; Article no.AJBGMB.95962 ISSN: 2582-3698 First Report Occurrence of CIT and DHA AmpC β-lactamase Gene in Escherichia coli and Klebsiella pnuemoniae from Clinical Sample in South Eastern, Nigeria Peace Oluchi Akpu a , Henrietta Onyinye Uzoeto b , Ikemesit Udeme Peter a,c* , Onyinye Lovette Nomeh a , Agabus Chidiebube Nwuzo a , Rebecca Chinenye Ogba a,d and Ifeanyichukwu Romanus Iroha a a Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, P.M.B. 53, Nigeria. b Department of Microbiology, Faculty of Pure and Applied Science, Federal College of Dental Technology and Therapy, Trans Ekulu, P.M.B. 01473, Enugu, Nigeria. c Department of Public Health, Faculty of Health Technology and Engineering, Federal College of Dental Technology and Therapy, Trans-Ekulu, P.M.B. 01473, Enugu, Nigeria. d Department of General Studies, Science and Technology, Federal Polytechnic, Ohodo, P.M.B. 01801, Enugu, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors POA, RCO helped to conceptualized the data. Author POA did Data curation and Formal analysis. Authors HOU, ACN, IUP, IRI performed Methodology. Author POA did project administration. Authors IRI supervised the data and wrote the original draft. Authors IRI and IUP wrote, reviewed and edited the manuscript. All authors investigated the study, did literature searches and did data Validation and Visualization. All the authors reviewed and approved the final draft, and are responsible for all aspects of the work. Article Information DOI: 10.9734/AJBGMB/2023/v13i1285 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/95962 Received: 28/10/2022 Accepted: 30/12/2022 Published: 03/02/2023 Original Research Article