 Corresponding author: Obemeata E Oriakpono Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt P. M. B. 5323, Port Harcourt, Rivers State, Nigeria. Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0. Reproductive indices and haematological response of male albino rats (Rattus norvegicus) exposed to Carburetor cleaner Obemeata Emmanuel Oriakpono * and Rejoice Emekalam Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt P. M. B. 5323, Port Harcourt, Rivers State, Nigeria. World Journal of Advanced Research and Reviews, 2022, 13(03), 277–282 Publication history: Received on 30 January 2022; revised on 10 March 2022; accepted on 12 March 2022 Article DOI: https://doi.org/10.30574/wjarr.2022.13.3.0126 Abstract Albino rats were exposed to carburetor cleaners with varying routes of exposure using five treatments viz control group1, & groups 2, 3, 4 & 5 representing (inhalatory, feed incorporated, oral and dermal routes) respectively. Haematological parameters as; PCV, HB, RBC, McV, McH, and McHc were evaluated, while the semen analysis such as; Motility quantitative (M1), Debris quantitative (D1), sperm count (C), morphology primordial (Mp), and morphology structure (Ms) were determined. The results revealed the following mean value of PCV for groups 1, 2, 3, 4, and 5 as 47.5, 40.0, 35.0, 20.5, and 23.25 respectively with significant differences (P<0.05) across the group, for HB 15.38, 14.25, 12.10, 8.30 and 8.78 for group 1, 2, 3, 4 and 5 respectively with significant difference (P<0.05) across the group. RBC and McV had a mean value of 5.27 and 9.08, 4.15and 9.59, 3.57 and 10.01, 2.33 and 8.77, 1.85 and 14.66 for groups 1, 2, 3, 4, and 5 respectively with significant differences (P<0.05) across the group. While McH and McHc had a mean value of 2.94 and 0.32, 3.42 and 0.36, 3.45 and 0.35, 3.59 and 0.41, 5.51 and 0.39 for groups 1, 2, 3, 4, and 5 respectively with significant difference (P<0.05) across the group. For semen analysis, M1 was 66.25, 52.5, 43.75, 31.25 and 23.75 for group 1, 2, 3, 4 and 5 respectively, Debris D1 was 6.25, 7.5, 8.75, 28.75 and 7.5 for group 1, 2, 3, 4 and 5 respectively, C and Mp were 53.25 and 6.25, 47.5 and 6.25, 42.0 and 17.75, 36.25 and 27.50, 37.25 and 30.0 for group 1, 2, 3, 4 and 5 respectively also. Finally, Ms was 1.0, 1.0, 1.25, 1.50 and 1.75 for group 1, 2, 3, 4 and 5 respectively. The results generally indicate that carburetor cleaner exerts a negative effect on the body irrespective of the route of exposure and extreme care should be taken when handling and utilization. Keywords: Carburetor; Male albino rats; Reproductive indices; Haemoglobin; Anaemia; Occupational health 1. Introduction A carburetor is a device that mixes fuel and air together and pulling the mixture into the cylinders for combustion in an internal combustion engine [1]. Carburetors are vulnerable to accumulation of residues of petrol, and this affects its functionality. These residues require a strong solvent before it can be wiped clean [2]. Carburetor cleaners are chemical sprays which are used to remove residues that build-up and deposit on carburetors, it is designed to safely clean without damaging the gaskets, rubber and plastic parts [2]. They are either single can aerosols or come in gallon-sized portions; the toxic nature of the main ingredient makes it hazardous and hence requires a level of education and careful handling [3]. The carburetor cleaner is made up of oil and organic solvents, some of the organic solvents used include; Acetone, Xylene, Toluene, methyl ethyl ketone and ethyl benzene [2]. There have been many studies by different authors on the individual chemicals, but few on its possible synergetic effect considering that Carburetor cleaners contain more than one of these solvents. Automobile mechanics are the set of persons predisposed to the exposure of Carburetor cleaners, especially in developing countries where the level of education of the mechanics is usually low and adequate safety