Research Article Facile Fabrication of CuO Nanoparticles Embedded in N-Doped Carbon Nanostructure for Electrochemical Sensing of Dopamine Nebras Sobahi , 1 Mohd Imran , 2 Mohammad Ehtisham Khan , 3 Akbar Mohammad , 4 Md. Mottahir Alam , 1 Taeho Yoon , 4 Ibrahim M. Mehedi , 1,5 Mohammad A. Hussain, 1 Mohammed J. Abdulaal, 1 and Ahmad A. Jiman 1 1 Department of Electrical & Computer Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia 2 Department of Chemical Engineering, College of Engineering, Jazan University, P.O. Box 706, Jazan 45142, Saudi Arabia 3 Department of Chemical Engineering Technology, College of Applied Industrial Technology (CAIT), Jazan University, Jazan 45971, Saudi Arabia 4 School of Chemical Engineering, Yeungnam University, Gyeongsan-si, Gyeongbuk 38541, Republic of Korea 5 Center of Excellence in Intelligent Engineering Systems (CEIES), King Abdulaziz University, Jeddah, Saudi Arabia Correspondence should be addressed to Mohammad Ehtisham Khan; mehtishamkhan1@gmail.com, Akbar Mohammad; amohd.iiti@gmail.com, Md. Mottahir Alam; mohammad.mottahir@gmail.com, and Taeho Yoon; tyoon@yu.ac.kr Received 8 July 2022; Accepted 26 September 2022; Published 14 October 2022 Academic Editor: Guillermo Mendoza-Diaz Copyright © 2022 Nebras Sobahi et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the present study, a highly selective and sensitive electrochemical sensing platform for the detection of dopamine was developed with CuO nanoparticles embedded in N-doped carbon nanostructure (CuO@NDC). e successfully fabricated nanostructures were characterized by standard instrumentation techniques. e fabricated CuO@NDC nanostructures were used for the de- velopment of dopamine electrochemical sensor. e reaction mechanism of a dopamine on the electrode surface is a three- electron three-proton process. e proposed sensor’s performance was shown to be superior to several recently reported in- vestigations. Under optimized conditions, the linear equation for detecting dopamine by differential pulse voltammetry is I pa (μA)  0.07701 c (μM) − 0.1232 (R 2  0.996), and the linear range is 5-75 μM. e limit of detection (LOD) and sensitivity were calculated as 0.868 μM and 421.1 μA/μM, respectively. e sensor has simple preparation, low cost, high sensitivity, good stability, and good reproducibility. 1. Introduction Dopamine (DA) is a common hormone in the family of catechol ethylamine which works as a neurotransmitter. It affects the renal, nervous, and cardiovascular systems as well as endocrine system of mammals [1]. DA controls certain physiological conditions, such as movement, learning, memory, behavior, mood, and mental cognition [2, 3]. DA excites the heart and increases the blood flow. When do- pamine (DA) levels are low, people lose the ability to control muscles and continue to tremble. In severe cases, this leads to Parkinson’s, Alzheimer’s, schizophrenia, and other symptoms [2, 4]. e neurological disorders, depression, autism, congenital cardiopathy, hypertension, bronchial asthma, and septic shock are treated using DA clinically [5]. Due to such important uses and function of DA in human body, it is necessary to detect DA concentration very ac- curately. Among various methods of detection, electro- chemical sensing is a proficient method which detects the biological molecules in very low detection range with high sensitivity and good selectivity [6, 7]. Nanoparticles play an important role in electrochemical detection and are widely used in electrode fabrication for chemical sensors and bio- sensors [8–11]. Apart from electrochemical sensing appli- cations, nanostructured materials are extensively used in various applications, such as heat transfer, photocatalysis, Hindawi Bioinorganic Chemistry and Applications Volume 2022, Article ID 6482133, 9 pages https://doi.org/10.1155/2022/6482133