International Surgery Journal | May 2019 | Vol 6 | Issue 5 Page 1646 International Surgery Journal Saxena MK et al. Int Surg J. 2019 May;6(5):1646-1649 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 Original Research Article Study of demographic determinants of H. pylori infection and the implications on endoscopic findings M. K. Saxena 1 , Rooman Ahmad Rana 1 *, Ashutosh Gupta 1 , Ausaf Ahmad 2 INTRODUCTION Helicobacter pylori infection is a known Carcinogen, as classified by The International Agency for Research on Cancer. It has been suggested from a number of studies that presence of H. pylori is associated with a spectrum of gastrointestinal conditions like gastritis, dyspepsia, epigastric pain, and Cancer. 1-5 It is also a known fact that gastric cancer shows a significant predilection in males as compared to females. 6 While, the fact that Gastric cancer is more common in elderly population would suggest an age linked association, some studies do not support this association. However, no significant variation in gender specific incidence of H. pylori has been observed. 7 However, it is also a known factor in pathogenesis of gastric and duodenal ulcer, as well as being associated with reflux diseases. Epidemiological studies have shown that areas with high gastric cancer rates often have a correspondingly high prevalence of Helicobacter pylori. 8 The mode of transmission of H. pylori remains poorly understood; no single transmission pathway has been identified. 9 This study was conducted among patients who underwent upper gastrointestinal endoscopy (UGIE) carried out in patients suspected to be suffering from gastroduodenal symptoms and signs with following objectives: ABSTRACT Background: Helicobacter pylori plays an important role in management of dyspepsia, as well as being a known carcinogenic risk factor. It is ubiquitously present in community to the extent of 50-80% in different studies depending upon the sampling from an urban area or a rural area, as well as socio-economic factors, as also the fact it is a risk factor for carcinoma in elderly age group and Peptic ulcer disease in relatively younger population. The study aimed at studying demographic profile in terms of the age and gender of patients, ascertaining its correlation with H. pylori. Methods: This is a retrospective descriptive study based on the upper GI endoscopies carried out in the institution. The period covered was from 01 January 2018 to 31 December 2018. The inclusion and exclusion criteria were well defined. Statistical analysis was carried out using SPSS Version 16.0 Chi-Square was applied. Results: This is a retrospective descriptive study based on the upper GI endoscopies carried out in the institution. The period covered was from 01 Jan 2018 to 31 Dec 2018. The inclusion and exclusion criteria were well defined. Statistical Analysis was carried out using SPSS Version 16.0 Chi-Square was applied. Conclusions: The study confirms the relationship of age and gender with presence or absence of H. pylori infection. Keywords: H. pylori, Endoscopy, Age, Gender association 1 Department of Surgery, 2 Department of Community Medicine, Integral Institute of Medical Sciences and Research, Kursi Road, Lucknow, Uttar Pradesh, India Received: 01 March 2019 Revised: 02 April 2019 Accepted: 03 April 2019 *Correspondence: Dr. Rooman Ahmad Rana, E-mail: njmsonline@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-2902.isj20191884