MF Vol 18 No 4, 2022 | DOI : 10.22146/farmaseutik.v18i4.66531 415 Majalah Farmaseutik Vol. 18 No. 4: 415-426 ISSN-p : 1410-590x ISSN-e : 2614-0063 Profil Skala Nyeri dan Kadar Interleukin-6 pada Pasien Ulkus Kornea Bakteri di RS Mata “Dr. YAP” dan RSUP Dr. Sardjito Berdasarkan Profil Terapi: Prospective Case Series Pain Scale and Interleukin-6 Concentration Profile in Bacterial Corneal Ulcer Patient Based on Therapy Profile: Prospective Case Series Bani Adlina Shabrina 1 , Ika Puspitasari 2* , Suhardjo Pawiroranu 3 1 Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada 2 Departemen Faramkologi & Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada 3 Departemen Ilmu Kesehatan Mata, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan Corresponding author: Ika Puspitasari: Email: ika.puspitasari@gmail.com Submitted: 11-06-2021 Revised: 19-07-2021 Accepted: 23-07-2021 ABSTRAK Ulkus kornea merupakan kondisi kegawatdaruratan mata yang sebagian besar disebabkan oleh bakteri. Parameter klinik utama ulkus kornea bakteri adalah skala nyeri, di mana interleukin-6 (IL-6) merupakan sitokin pro-inflamasi yang berperan penting. Penelitian ini bertujuan untuk mengetahui profil skala nyeri dan kadar IL-6 pada pasien ulkus kornea bakteri di RS Mata “Dr.YAP” dan RSUP Dr. Sardjito berdasarkan profil terapi. Jenis penelitian ini merupakan penelitian observasional deskriptif dengan rancangan penelitian prospective case series. Subjek penelitian adalah pasien ulkus kornea bakteri di RS Mata “Dr.YAP” dan RSUP Dr. Sardjito selama Agustus-Oktober 2020. Parameter perbaikan klinik dalam penelitian ini adalah penurunan skala nyeri dan kadar IL-6 sebelum subjek penelitian memperoleh terapi (pre) dan setelah kondisi kliniknya dinyatakan membaik (post). Sebanyak 6 (enam) subjek penelitian diikutsertakan dalam penelitian ini. Rata-rata penurunan skala nyeri dan kadar IL-6 berturut-turut sebesar 3,17 dan -4972,60 pg/mL. Seluruh profil skala nyeri subjek penelitian mengalami perbaikan. Namun, profil kadar IL-6 hanya membaik pada 1 (satu) subjek penelitian (16,67%). Sedangkan profil kadar IL-6 dari 5 (lima) subjek penelitian lain (83,33%) mengalami perburukan akibat beberapa faktor, antara lain, tidak diberikannya terapi non farmakologi pada tingkat keparahan berat, usia lanjut, post Laser-Assisted In Situ Keratomileusis (LASIK), dan etiologi berupa Staphylolcoccus aureus. Disarankan penelitian lebih lanjut dengan jumlah sampel yang lebih besar dan desain penelitian cohort untuk mengetahui hubungan karakteristik pasien dan profil terapi terhadap perbaikan klinik ulkus kornea bakteri. Kata kunci: ulkus kornea bakteri; kadar interleukin-6; skala nyeri; profil terapi. ABSTRACT Corneal ulcer is an ophthalmologic emergency condition, which mostly caused by bacterial infection. The main clinical parameter in bacterial corneal ulcer is pain scale, whose interleukin-6 (IL-6) is the main pro-inflammatory cytokine. This study aimed to know pain scale profile and IL-6 concentration in bacterial corneal ulcer patient at RS Mata “Dr.YAP” dan RSUP Dr. Sardjito based on therapy profile. This is an observational study with prospective case series study design. This study involved subjects with bacterial corneal ulcer at RS Mata “Dr.YAP” dan RSUP Dr. Sardjito on August – October 2020. Clinical improvement parameters are the decrease of pain scale and IL-6 concentration which measured before therapy (post) and after recovered (post). There were 6 (six) subjects involved in this study. The mean of the decrease of pain scale and IL-6 concentration are 3,17 and -4972,60 pg/mL consecutively. Pain scale profile in all subjects improved based on therapy profile. But, IL-6 concentration profile only improved in 1 (one) subject (16,67%). Interleukin-6 concentration profile in five other subjects (83,33%) worsened caused by some factors, such as, the absent of non pharmacological therapy, advanced age, and post Laser- Assisted In Situ Keratomileusis (LASIK), Staphylolcoccus aureus etiology. Further study with larger sample and cohort study design is recommended to be conducted in order to know the relationship between patient characteristic and therapy profile to bacterial corneal ulcer clinical improvement. Keywords: bacterial corneal ulcer; interleukin-6 concentration; pain scale; therapeutic profile.