1540 © 2021 Annals of Medical and Health Sciences Research Original Article Research Article Abstract Background: Computer Vision Syndrome (CVS) described by the American Optometric Association (AOA) as “The complex of eye and vision problems related to near work experience during computer use.” The current study aims to evaluate the prevalence of CVS and the association between CVS symptoms with age and behavior’s, among college students and employees in Jeddah, Saudi Arabia. Subjects & Methods: This was a cross-sectional analytic study conducted in Jeddah, Saudi Arabia from July to August 2020. The study targets college students and employees living in Jeddah, Saudi Arabia, from July 2020. The target sample size was a minimum of 377 that was calculated using raosoft. Data entry was performed by Microsoft Excel 2019, and analysis was done using Statistical Package for the Social Sciences (SPSS) software, version 25. Frequency, descriptive analysis, Chi-square, and One-way ANOVA was performed. P-value of <0.05 was considered statistically signifcant. Results: Overall, 786 responses were received, only 459 met the criteria of which 277 (60.3%) were college students and 182 (39.7%) were employees. Pain in and around the eyes 288 (66.5%) and sore eyes 247 (57%) were the most commonly reported ocular symptoms among participant and in terms of extra-ocular symptoms; headache 355 (82%) and neck and shoulder pain 237 (55%) recorded highest. The highest number of symptoms was reported by IbnSina National College (ISNC) students with approximately a mean number of symptoms 7 ± 3.443. Conclusion: Computer Vision Syndrome is a common syndrome among college students and employees. Keywords: Computer vision syndrome; Prevalence; Risk factors; Jeddah; Saudi Arabia; Computer users; Ocular symptoms Corresponding author: Yumna A Bokhari, Department of Medicine, IbnSina National College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia, Tel: +966533629892; E-mail: yumnabokhari942@gmail.com How to Cite this Article: Al-Manjoumi AM, et al. Risk Factors of Computer Vision Syndrome among College Students and Employees in Jeddah. Ann Med Health Sci Res. 2021;11:1540-1545. This is an open access article distributed under the terms of the Creative Com- mons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. Risk Factors of Computer Vision Syndrome among College Students and Employees in Jeddah Ahmed M Al-Manjoumi 1,2 , Yumna A Bokhari 3 *, Abdullah S Alsubaie 3 , Ahlam Y Lasker 4 , Atheer A Alshanbari 5 and Rahaf O Alamri 5 1 Department of Medicine, King Abdul-Aziz University, Rabigh, Kingdom of Saudi Arabia; 2 Department of Medicine, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia; 3 Department of Medicine, IbnSina National College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia; 4 Department of Medicine, King Abdul-Aziz University, Jeddah, Kingdom of Saudi Arabia; 5 Department of Medicine, Taif University, Taif, Kingdom of Saudi Arabia Introduction Computer Vision Syndrome symptoms are classifed into ocular symptoms such as eye strain, blurry vision, and dry eyes, and extraocular symptoms which includes pain in the neck or shoulders or numbing in the hands or fngers. [1] CVS is a growing public health problem that is not clearly understood. [2] The usage of computers and other digital devices for an extended period causes the rise of CVS symptoms later on in the future. [1,3] AOA found that 14% of patients who visit the ophthalmology clinic for visual examinations have CVS. [4] On average more than 50% of the work environment now uses computers in their job; thus, nearly 60 million people experience ocular problems. [5] The most frequently occurring health problem among computer users are CVS, [6–9] followed by wrist and shoulder pain and overuse syndrome to musculoskeletal injuries. [10,11] Subjects and Methods The study was approved by Dr. Soliman Fakeeh Hospital Scientifc Research Review Committee (DSFH IRB). It was a cross-sectional analytic study conducted in the Jeddah region of Saudi Arabia from July to August 2020. The study targets college students and employees in Jeddah, Saudi Arabia. Those diagnosed with underlying systemic diseases (diabetes, hypertension, hypothyroidism, hyperthyroidism), who had pre-existing eye diseases (such as Glaucoma, Sjogren syndrome, LASIK surgery done less than a year), they’re not employees nor college students and those who wear contact lenses were excluded. The target sample size was a minimum of 377 that was calculated using Raosoft software. A validated electronic questionnaire was taken from a study conducted in Sri Lanka that was used for measuring the CVS symptoms. [12] The used survey was translated into Arabic and subjected to a process of forward and backward translation. All information in this study was confdential, and the