International Journal of Research in Medical Sciences | July 2019 | Vol 7 | Issue 7 Page 2563 International Journal of Research in Medical Sciences Elahi W et al. Int J Res Med Sci. 2019 Jul;7(7):2563-2567 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Calcium levels and metabolic disturbance in renal disease patients receiving hemodialysis: a cross sectional study highlighting its association in dialysis patients Wajeeha Elahi 1 , Ameen Zubair Syed 1 , Bilal Jamil 2 , Madiha Ariff 3 *, Nazia Qamar 4 , Raheela Adil 5 , Adnan Anwar 5 INTRODUCTION Both morbidity as well as mortality in patients on hemodialysis remains exceptionally high. 1 Since hemodialysis accompanies profound change in mineral metabolism, abnormal metabolism of minerals leads towards metabolic diseases of bone. 2 Minerals and bone disorder (MBD) is a predictable complication of dialysis 1 Department of Nephrology, 2 Medical Director, Tabba Kidney Institute, Karachi, Sindh, Pakistan 3 MBBS, Dow Medical College, Karachi, Sindh, Pakistan 4 Department of Pathology, 5 Department of Physiology, Altibri Medical college, Karachi, Sindh, Pakistan Received: 3 February 2019 Revised: 21 March 2019 Accepted: 28 March 2019 *Correspondence: Dr. Madiha Ariff, E-mail: madiha.ariff@live.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: The aim of this study was to determine the disturbances in Calcium and other mineral levels in patients on hemodialysis at Tabba Kidney Institute, Karachi, Sindh, Pakistan. Methods: A cross sectional observational study through convenient sampling technique was conducted from January 2017 to August 2017 at Tabba Kidney Institute, Karachi after obtaining ethical approval. 255 patients, all above 18 years of age and on hemodialysis were included in the study. Multi-organ failure patients on dialysis, other systemic diseased patients on hemodialysis were excluded. Demographic variables, mineral levels, symptoms and supplementations were recorded. SPSS version 20.0 was used for data analysis. Results: A total of 255 patients on hemodialysis were selected and divided into groups depending upon median years of hemodialysis below and above 5 years of hemodialysis. Median and IQR of calcium were 8.8 and 8.2-9.1 mg/dl for below 5 years, 8.6 and 8.1-9.1 mg/dl for above 5 years (P value=0.44). Median and IQR of phosphate were 4.9 and 3.9-5.7 mg/dl for below 5 years and 4.6 and 3.7-5.5 mg/dl for above 5 years (P value=0.21). Median and IQR of parathyroid hormone were 393 and 212-699 pg/ml for below 5 years and 329 and 128-657 pg/ml for above 5 years. (P value=0.13) Median and IQR of albumin were 4.0 and 3.6-4.2 mg/dl for below 5 years and 4.0 and 3.8-4.3 for above 5 years (P value=0.30). Total of 18 (10.9%) had para thyroidectomy. Conclusions: Present study showed that significant difference in mineral levels did not exist in patients on hemodialysis as regards to the duration of dialysis. However clinical features had a tendency to decrease as duration of dialysis increased to above 5 years. Para thyroidectomy and itching were two main significant findings in this study. Keywords: Calcium, Cross sectional study, Developing country, Hemodialysis, Metabolic disturbance, Renal disease DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20192878