Research Article
Capacity Evaluation of Diagnostic Tests For COVID-19 Using
Multicriteria Decision-Making Techniques
Murat Sayan,
1,2
Figen Sarigul Yildirim,
3
Tamer Sanlidag,
2,4
Berna Uzun,
2,5
Dilber Uzun Ozsahin ,
2,6
and Ilker Ozsahin
2,6
1
Faculty of Medicine, Clinical Laboratory, PCR Unit, Kocaeli University, Kocaeli, Turkey
2
DESAM Institute, Near East University, Nicosia/TRNC, Mersin-10, 99138, Turkey
3
Health Science University, Antalya Education and Research Hospital, Department of Infectious Diseases and Clinical Microbiology,
Antalya 07050, Turkey
4
Department of Medical Microbiology, Manisa Celal Bayar University, Manisa, Turkey
5
Department of Mathematics, Near East University, Nicosia/TRNC, Mersin-10, 99138, Turkey
6
Department of Biomedical Engineering, Faculty of Engineering, Near East University, Nicosia/TRNC, Mersin-10, 99138, Turkey
Correspondence should be addressed to Ilker Ozsahin; ilker.ozsahin@neu.edu.tr
Received 11 May 2020; Revised 22 June 2020; Accepted 7 July 2020; Published 6 August 2020
Guest Editor: Plácido R. Pinheiro
Copyright © 2020 Murat Sayan et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus.
This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual
comparison among existing SARS-CoV-2 diagnostic tests and at determining the most effective one. Based on available
published evidence and clinical practice, diagnostic tests of coronavirus disease (COVID-19) were evaluated by multi-criteria
decision-making (MCDM) methods, namely, fuzzy preference ranking organization method for enrichment evaluation (fuzzy
PROMETHEE) and fuzzy technique for order of preference by similarity to ideal solution (fuzzy TOPSIS). Computerized
tomography of chest (chest CT), the detection of viral nucleic acid by polymerase chain reaction, cell culture, CoV-19 antigen
detection, CoV-19 antibody IgM, CoV-19 antibody IgG, and chest X-ray were evaluated by linguistic fuzzy scale to compare
among the diagnostic tests. This scale consists of selected parameters that possessed different weights which were determined
by the experts’ opinions of the field. The results of our study with both proposed MCDM methods indicated that the most
effective diagnosis method of COVID-19 was chest CT. It is interesting to note that the methods that are consistently used in
the diagnosis of viral diseases were ranked in second place for the diagnosis of COVID-19. However, each country should use
appropriate diagnostic solutions according to its own resources. Our findings also show which diagnostic systems can be used
in combination.
1. Introduction
After cases of pneumonia of unknown cause were detected in
Wuhan, China, in December 2019, a new coronavirus was
isolated from human airway epithelial cells and was named
severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), which is responsible for coronavirus disease
(COVID-19) [1]. SARS-CoV-2 is also a member of the coro-
navirus family that includes Middle East Respiratory Syn-
drome- (MERS-) CoV and SARS-CoV, which infect
humans [1, 2]. Wild animals are the source of the infection.
According to phylogenetic analysis of full genome
sequencing, the coronavirus that causes COVID-19 is a beta-
coronavirus in the same subgenus clade as SARS-CoV-2. The
structure of the receptor binding site for cell entry is similar
and uses the angiotensin-converting enzyme 2 receptor
found in the epithelial cells of the alveoli used by SARS-
CoV-2 [3]. The International Committee on Taxonomy of
Viruses has proposed that this virus be designated as SARS-
CoV-2 [3, 4].
The main mode of transmission is via person-to-person
spread. When an infected person coughs, sneezes, or speaks,
Hindawi
Computational and Mathematical Methods in Medicine
Volume 2020, Article ID 1560250, 8 pages
https://doi.org/10.1155/2020/1560250