221 Erciyes Üniv Vet Fak Derg 11(3) 221-225, 2014 Z.K. SARITAŞ, M.F. BOZKURT, M. KORKMAZ, .D. BAŞER, T. CİVELEK Hepatocellular Carcinoma in a Dog Zülfikar Kadir SARITAŞ 1 , M Fatih BOZKURT 2 , Musa KORKMAZ 1 , F.Durmuş BAŞER 3 , Turan CİVELEK 3 1 Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Surgery, Afyonkarahisar-TURKEY 2 Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology, Afyonkarahisar-TURKEY 3 Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Internal Medicine, Afyonkarahisar-TURKEY Summary: A female Terrier dog with the age of 11 was brought to our hospital with complains of anorexia, loss of weight, lethargy and abdominal swelling. In the abdominal palpation, a mass extending towards the caudal in the right quadrant was identified. Presence of a mass was confirmed in the direct radiographic examination, which supports the clinical finding. In the abdominal ultrasonography it was determined that the liver had lost its homogenous structure, there was free fluid in the abdomen, and the liver borders were irregular. The ALP, total protein, ALB and GGT were identified as 328 IU/L, 2.74 g/dl, 1.85 g/dl and 12.2 U/I respectively in the biochemical analysis. Experimental laparotomy was applied to the case and a diffused mass was identified in the liver. Samples were taken from the neoplastic masses during the operation and the abdomen was closed after identifying diffused neoplastic formations in all lobes. Following the histo-pathological examination of the sample, the patient was diagnosed with hepatocellular carcinoma. In this paper, it was aimed to report the clinical, radiological, ultrasonographic, biochemical and haematological findings of a hepatocellular carcinoma observed in a dog. Key Words: Biochemical analysis, dog, hepatocellular carcinoma, ultrasonography Bir Köpekte Hepatosellüler Karsinom Özet: 11 yaşlı dişi Terrier ırkı köpek, anoreksi, zayıflama, uyuşukluk ve abdominal genişleme şikayetleriı ile hastane- mize getirilmiştir. Abdominal palpasyonda abdomenin sağ kadranında kaudale doğru uzanan kitle belirlenmiştir. Olguda direkt radyografik muayenede klinik bulguyu destekleyen kitle varlığı teyid edilmiştir. Abdominal ultrasonografide kara- ciğerin homojen yapısını kaybettiği, abdomende serbest sıvı varlığı belirlenmiş ve karaciğer sınırlarının düzensiz oldu- ğu saptanmıştır. Biyokimyasal analizde ALP’nin 328 IU/L, total proteinin 2.74 g/dl, ALB’in 1.85 g/dl, GGT’nin 12.2 U/l olduğu belirlendi. Deneysel laparotomi yapılan olguda karaciğerde yaygın kitle varlığı belirlendi. Operasyon sırasında tümöral kitlelerden örnekler alınarak tüm loplarda yaygın tümöral oluşumların varlığının belirlenmesi üzerine abdomen kapatıldı. Alınan örnekten yapılan histopatolojik incelemede hepatosellüler karsinom tanısı kondu. Sonuç olarak bir köpekte rastladığımız hepatosellüler karsinom olgusunun; klinik, radyolojik, ultrasonografik, biyokimyasal ve hematolo- jik bulgularının paylaşılması amaçlanmıştır. Anahtar Kelimeler: Biyokimyasal analiz, hepatosellüler karsinom, köpek, ultrasonografi Introduction It is reported that the primary hepatocellular tumors (Hepatocellular carcinoma, hepatoma) are rarely seen in animals (6). Hepatocellular Carcinoma (HCC) is most frequently observed in dogs and cattle and less often in pigs and cats (6). Canine HCC is divided into three morphological groups as massive, nodular and diffuse, and massive lesion which involves a single liver lobe is the most common one (4). Liver lobectomy is the recommended therapy method and prognosis after surgical excision is reported to be good in dogs (4). It is defined in the literature that the ultrasonographic findings of the cellular carcinoma commonly vary depending on a single or multiple focal lesion presence or wide hepatic mass presence (hyperechoic, hypoechoic, mix) (3). In the present case presentation, it is aimed to report the HCC case diagnosed in a dog admitted to our hospital. Case Presentation A female Terrier dog with the age of 11 which was admitted to Afyon Kocatepe University Veterinary Faculty Animal Hospital and displayed complains of loss of appetite and abdominal swelling in the last two weeks constituted the material of the case presentation. The case had a breast cancer surgery 3 years ago. The abdomen was hanging and stretched and a mass in the abdomen that Geliş Tarihi/Submission Date : 10.01.2014 Kabul Tarihi/Accepted Date : 26.02.2014 Erciyes Üniv Vet Fak Derg 1(1) 1- Olgu Sunumu J Fac Vet Med Univ Erciyes 1(1) 1- Case Report ERCİYES ÜNİVERSİTESİ VETERİNER FAKÜLTESİ DERGİSİ Journal of Faculty of Veterinary Medicine, Erciyes University Olgu Sunumu / Case Report Olgu Sunumu / Case Report 11(3), 221 11(3), 221-225, 2014 225, 2014