International Journal of Science and Research (IJSR) ISSN (Online) : 2319-7064 Index Copernicus Value (2013) : 6.14 | Impact Factor (2015) : 6.391 Volume 5 Issue 5, May 2016 www.ijsr.net Licensed Under Creative Commons Attribution CC BY Study Effect of Blood Glucose Level on Renal Failure in Peoples Suffering from Diabetes A.L Basim M. Ali Department of Chemistry, College of Science, Al-Kufa University, Iraq Abstract: This study was accompanied in AL-Emam AL-Sajjsd hospital in al najaf al ashraf city through the period from May 2015 to September 2015. To evaluate serum lipid profile, albumin and Hb in patients, it involved 77 patients, 53 male and 24 females’ patients, and their range of age from 21 to 65 years. The patient was identified as suffering (renal failure caused by diabetic) for both gender based on the history, clinical analysis test for renal function and DM. The control groups were 50; they were collected from medical staff and relatives who were free of kidney disease, diabetes and hypertension. Number of men is thirty and twenty women; the ages range btween twenty-two and sixty-six years. The samples of blood were take from the case (8-12) hours after night fasting, One of the most important causes that cause renal failure is diabetes by causing hurt to blood vessels in the organ (kidney) the units of filtering in the kidney are filled with small blood vessels. For along time, high glucose levels in the blood can cause narrow and clogged. The changes in parameters btween the levels in both male and female patients and their control, a positive significant change in (Uric acid, Blood glucose{Sugar}, Urea, Creatinine, K, PO4, GOT, GPT, Iron, Ferretin, TIBC, UIBC, TS%, ETIBS) levels of male patients as compared with the control group, the same table states to negatively significant changing in levels of (Ca, Alb, Hb, PCV) in the tow gender patients with renal failure as paralleled with group of control. Just one item shows on significant change the item is Na when we compared with their control group. The effect of high blood sugar levels leads to many complications in vital human. There are no direct relationship between high blood sugar and diabetes on the hand versus the low level of hemoglobin or high level iron status on the other hand Keywords: Renal failure, Diabetes mellitus, hyperglycaemia, Iron status, Hemoglobin 1. Indroduction Diabetes is a extreme disease. It occurs when the body can not produce enough amount of insulin which is a hormone controls the amount of glucose in blood. Increase blood sugar level can cause problems in main parts of human body."Diabetes mellitus" (DM) is the keypurpose of "end- stage renal disease" (ESRD). Contrariwise, "chronic renal failure" (CRF) is attendant with variant adaptations in metabolism of insulin and carbohydrate this definition described by. (Pedro Iglesias1 and Juan J.2007), (Rabkin R, Ryan MP. 1984). (Schmekal B. 2002) explained that the modifications in the carbohydrate metabolism, especially chronic hyperglycaemia, ordinarily affect on renal function. For the time being, diabetic nephropathy appoints the greatestpublicreason of CRF. Additionally the hyperperfusion (escalation in glomerular movement), hypertension and kidney"hypertrophy" are the main variation concomitant with high blood glucose (hyperglycaemia) in "diabetic nephropathy" this study produced by (Maeda M. Et al 2004). Also (Scholey Jw and Meyer TW.1989) expounded The "hypertension in glomerular capillary"detected in hyperglycaemia (DM) would represent to be a complications of the lack of insulin achievement as stern glycaemic control lower both kidney haemodynamic and renal size response Sundry moderators serve to preserve glomerular hyperfiltration associated with kidney damage. Many studies testified that perfect glycaemic dominance in the before dialysis is main in taminglong-standing assessment in (DM) patients on dialysis. Fine blood sugar control before dialysis was compact interconnected with morbidity (Heart disease, malnutrition and DM complications) this studies reported by (Morioka T et al 2001), (Wu MS et al 1999). The relationship between high blood glucose and chronic renal failure and effect of glucose and microalbuminuria in damage of glomerulus as showen as in this schem. (Pedro Iglesias1 and Juan J.2007) and (Biesenbach G. Et al 2003) Figure 1: Schematic shows the relationship of insulin and its effects on the kidneys 2. Subjects and Methods A-Patients: 77 patients, 53 male and 24 females patients, their range of age from 21 to 65 years These patients were accompanied in AL-Emam AL-Sajjsd hospital in al najaf al ashraf city, the patient was identified as suffering (renal failure caused by diabetic) for both gender based on the history, clinical analysis test for renal function and DM. B-Controls: The control groups were 50; they were collected from medical staff and relatives who were free of kidney disease, diabetes and hypertension. 30 were males and 20 females, their ages range from 22 to 66 years. Paper ID: NOV163855 2033