Current Trends in Pharmacy and Pharmaceutical Chemistry 2023;5(1):38–41 Content available at: https://www.ipinnovative.com/open-access-journals Current Trends in Pharmacy and Pharmaceutical Chemistry Journal homepage: https://www.ctppc.org/ Original Research Article Formulation and evaluation of herbal syrup of kalmegh extract Amit Gajanan Nerkar 1,2,3, *, Rushikesh Nagarkar 1 , Shubhangi Badar 1 1 Dept. of Pharmacy, CAYMET’s Siddhant College of Pharmacy, Sudumbare, Pune, Maharashtra, India 2 Ateos Foundation of Science Education and Research, Pune, Maharashtra, India 3 Carolene Therapeutics, Pvt. Ltd, Aurangabad, Maharashtra, India ARTICLE INFO Article history: Received 02-03-2023 Accepted 10-03-2023 Available online 04-04-2023 Keywords: Herbal Syrup Kalmegh A paniculata Evaluation ABSTRACT The cultivation of Kalmegh (Andrographis paniculata), a plant with many medicinal benefits, has increased its importance as a medicinal plant. Considering the beneficial properties of the plant, it can be appreciated as a safe and important herb for humans. There are many different chemical constituents in this herb, but the main ones are lactones, diterpenoids, diterpene glycosides, flavonoids and flavonoid glycosides. It has a wide range of pharmacological effects, including antibacterial, hepatoprotective, antitumor, antitumor, hypoglycemic, immunomodulatory, and antihypertensive. Lab scale formulation is made with herbal syrup and evaluated for several parameters like pH, viscosity, density, stability test while evaluating the formula. is a stable and ready-to-know recipe. F1, F2, F3 and F4 are made with different amounts of ingredients such as alcohol, sugar and a final amount of syrup. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction 1.1. Kalmegh Most of the world’s population, especially in less developed countries, mainly depends on traditional doctors and herbal medicines to meet their basic health needs. 1 The association with conventional drugs poses a number of problems. For this reason, experts have recently revised their assessment of many medicinal plant species based on the differences between the species and their therapeutic potential. It is therefore essential to review previously published literature on this species to refresh our knowledge of them. Andrographis paniculata is one of them (Acanthaceae). It includes about 40 species and has been around for millennia. It is native to India Sri Lanka and is also distributed in different parts of Southeast * Corresponding author. E-mail address: dragnerkar@gmail.com (A. G. Nerkar). Asia, China, America and the West Indies. It grows well in almost any soil so it is widely distributed. It has been cultivated for its recognized therapeutic potential. 2 The aerial parts and roots of A.paniculata have been widely used in the treatment of various diseases. He is called Mahatikta in (Sanskrit), Kiryato in (Gujarati), Mahatita in (Hindi) and Kalmegh in (Bengali). 3 Various studies have been done by researchers, followed by reports on the therapeutic potential of this herb. Phytochemical studies show that A.paniculata contains various compounds such as diterpenoid lactones, flavonoids and various compounds. Due to their presence, it has many pharmacological properties. 4–6 This phytochemistry and pharmacological properties of A.paniculata (extracts and compounds) shows it has potential antimicrobial antioxidant, anti-inflammatory protozoa, antidiabetic, anti-infective, immunostimulating, hepatoprotective, sex hormone regulation, liver enzyme modulation, cytotoxicity, insecticidal, neuroprotective https://doi.org/10.18231/j.ctppc.2023.009 2582-5062/© 2023 Innovative Publication, All rights reserved. 38