ZANCO Journal of Pure and Applied Sciences The official scientific journal of Salahaddin University-Erbil ZJPAS (2017), 29 (s4); s139-s145 Sialic acid concentration changes in acute lymphocytic leukemia and acute mylogenous leukemia patients after chemotherapy treatment Jian Lateif Hussein 1 , Kamaran K. Abdoulrahman 1 , Husny M. Hassan 2 , and Hardi Q. Hamad 3 . 1 Department of Chemistry, College of Science, Salahadeen University, Erbil, Kurdistan Region-Iraq. 2 Department of Biochemistry, College of Medicine, Dohok University, Dohok, Kurdistan Region-Iraq. 3 Department of Chemistry, Koya Technical Institute, Koya, Kurdistan Region-Iraq. 1. INTRODUCTION Sialic acids (SAs) could be defined as O or N – acetyl derivatives another acid which is Neuraminic, where it is nine carbon sugar that also derived from Mannosamine (Collins, 1987). It plays a big role in human’s biochemical function because its constituents of Glycoproteins .SAs found in some cells that are negative charge (Langana et al.,1995), where it is valuable for cell to cell infarctions, immunological reaction, receptor function and cell recognition (Yoko et al,.1983),(Weigant,1985). Increased SA concentrations during the process of inflammatory have found by Sillanankee et A R T I C L E I N F O A B S T R A C T Article History: Received: 01/06/2017 Accepted: 05/08/2017 Published: 20/12/2017 Sialic acid—rich glycoprotein binds selectively in human and other organisms cancer cells that can metastasize .This helps these late stage cancer cells enter the blood stream. Biological markers can be used to monitor cancer elevation in the serum. Total sialic acid (TSA) concentration was observed in a number of cancer types, the chemotherapy is used as the only cancer treatment. The present study included 5l patients age (4—69 year) with leukemia, they were included 13 patients with acute lymphoblastic leukemia (ALL), 13 with acute myelogenous leukemia (AML) and 25 with chronic lymphocytic leukemia (CLL). This study included also 50 healthy subjects as normal control, all the patients had chemotherapy. The study included measurements of fasting serum total sialic acid (STSA) level, which is significantly increased in post sampling of leukemia patients compared with normal control subjects. A higher significant difference of STSA at the first week during chemotherapy in the three type of the leukemia patients, also there were significant difference of STSA level at the third week during chemotherapy in the ALL and AML patients. On the other hand, there were no significant differences in STSA level after five weeks of chemotherapy treatment for ALL and AML patients. According the duration of chemotherapy dose there were significant differences in STSA level between the first dose week and third dose of chemotherapy. Also, there were significant differences between the first weeks and 5th weeks of chemotherapy treatment for ALL and AML patients. Keywords: Sialic acid Leukemia Chemotherapy. *Corresponding Author: Jian L. Hussein (jian.hussen@su.edu.krd) http://dx.doi.org/10.21271/ZJPAS.29.s4.16