. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Abstracts S253 with adult congenital heart disease (ACHD) and other PAH aetiology Aims: To compare echocardiographic measurements between patients with ACHD and other PAH. Methods: Retrospective analysis was performed on 25 patients from the PAH clinic with transthoracic echocardio- grams (TTE). Demographic and echocardiographic data was collected. Patients were compared to 25 age-matched controls from a departmental dataset. Results: Of the 25 PAH patients, 12 were male (48%) (mean age 44 years). 15 (60%) patients had ACHD and 10 (40%) had other PAH. 9 (18%) patients were NYHA III and all were on advanced therapies at time of analysis. LVESV was signifi- cantly larger in ACHD group versus PAH group and controls (45 ± 17 vs 30 ± 14 vs 34 ± 12 ml, p = 0.03). There was no sig- nificant difference in LVEDV, LVEF or indexed LA volume between the groups. RV (tricuspid) peak E velocity was signif- icantly higher in the ACHD group (0.9 ± 0.3 m/s) versus other PAH (p = 0.03) and normal controls (p < 0.001) There were significant differences between RA indexed volume, RVOT diameter, RIMP, S’, FAC and RVEF between all PAH patients and normal controls (p < 0.05) with no differences between ACHD and other PAH groups. Conclusions: RV peak E velocity was significantly higher in the ACHD group compared to other PAH and normal con- trols. While no significant difference was seen between ACHD versus PAH in RV measures, LVESV was larger in the ACHD group. http://dx.doi.org/10.1016/j.hlc.2017.06.481 481 Comparison of Single-View and Standard Assessment of Global Longitudinal Strain for Diagnosis of Cardiotoxicity T. Negishi 1 , P. Thavendiranathan 2 , S. Aakhus 3 , J. Lemieux 4 , M. Penicka 5 , G. Cho 6 , K. Hristova 7 , B. Costello 8 , P. Mottram 9 , M. Shirazi 10 , A. La Gerche 8 , L. Thomas 11 , K. Negishi 1 , T. Marwick 1,8,* 1 Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia 2 University of Toronto, Toronto General Hospital, Peter Munk Cardiac Centre, Toronto, Canada 3 Oslo University Hospital, Oslo, Norway 4 Centre de recherche du CHU de Québec, Québec, Canada 5 Cardiovascular Centre Aalst, OLV Clinic Belgium, Aalst, Belgium 6 Seoul National University Bundang Hospital, Seongnam, Republic of Korea 7 National Heart Hospital, Sofia, Bulgaria 8 Baker Heart and Diabetes Institute, Melbourne, Australia 9 Monash Medical Centre, Melbourne, Australia 10 Royal Adelaide Hospital, Adelaide, Australia 11 Westmead Hospital, Sydney, Australia Background: Global longitudinal strain (GLS) is a sensi- tive marker of LV dysfunction that facilitates early detection of cancer therapeutics related cardiac dysfunction (CTRCD). Standard GLS is derived from 3 apical views. However, as patients require repeated testing and CTRCD is a diffuse pro- cess, single view GLS could improve efficiency. We sought whether 4-chamber view GLS (4CV LS) could substitute GLS for the detection of CTRCD. Methods: 108 cancer patients receiving Anthracycline- based chemotherapy were enrolled. Ejection fraction (EF), GLS and 4CV LS were measured at baseline and follow-up, and the differences between them were calculated. Asymp- tomatic CTRCD was defined as EF > 0.10 decrease with to <0.55, or GLS > 12% decrease. A Bland-Altman plot (BA plot) was used for evaluation of concordance. Results: There were good correlations between GLS and 4CV LS at baseline and follow-up (r = 0.86 and 0.89, both p < 0.0001). BA plots demonstrated minimal bias (0.21 at base- line; 0.03 at follow-up) but modest limits of agreement (2.54% and 2.19%). Of 47 patients developing CTRCD, 4CV LS yielded 15 (14%) false negatives and 9 (8%) false positives, resulting in a discordance rate of 22% to detect CTRCD (Fig- ure).