Hematopoiesis and cell growth are differentially regulated by TAL1 isoforms Aveksha Sharma 1† , Shani Mistriel-Zerbib 2† , Rauf Ahmad Najar 1# , Eden Engal 1 , Mercedes Bentata 1 , Nadeen Taqatqa 1 , Sara Dahan 1 , Klil Cohen 1 , Shiri Jaffe-Herman 1 , Ophir Geminder 1 , Mai Baker 1 , Yuval Nevo 3 , Inbar Plaschkes 3 , Gillian Kay 1 , Yotam Drier 2 , Michael Berger 2 and Maayan Salton 1* . 1 Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel–Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel, 2 The Lautenberg Center for Immunology and Cancer Research, The Institute for Medical Research Israel–Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel and 3 Info-CORE, Bioinformatics Unit of the I-CORE Computation Center, and Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. † These authors contributed equally to this work. # Current address: Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. *To whom correspondence should be addressed. Tel: +972 26758814; Email: maayan.salton@mail.huji.ac.il Running head: TAL1 isoforms, hematopoiesis and cell growth Keywords: T-ALL, transcription factor, TAL1, hematopoiesis, cell growth . CC-BY-NC-ND 4.0 International license perpetuity. It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted December 26, 2022. ; https://doi.org/10.1101/2022.11.30.518304 doi: bioRxiv preprint