www.clinical.proteomics-journal.com Page 1 Proteomics - Clinical Applications Received: 27/04/2017; Revised: 14/09/2017; Accepted: 26/09/2017 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/prca.201700020. This article is protected by copyright. All rights reserved. Ubiquitin-conjugating enzyme E2 L3 is downregulated by the chikungunya virus nsP2 protease Suwipa Ramphan 1 , Sarawut Khongwichit 1 , Chonticha Saisawang 1 , Duangnapa Kovanich 1 , Albert J. Ketterman 1 , Sukathida Ubol 2,3 , Prasert Auewarakul 4 , Sittiruk Roytrakul 5 , Duncan R. Smith 1,3 and Atichat Kuadkitkan 1 * 1 Institute of Molecular Biosciences, 2 Department of Microbiology, Faculty of Science, 3 Center for Emerging and Neglected Infectious Diseases, 4 Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand, 5 National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand *Correspondence to: Atichat Kuadkitkan, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25/25 Phuttamontol Sai 4, Salaya, Nakorn Pathom, Thailand 73170. Tel (662) 800 3624-8; Fax (662) 4419906; Email: atichat.kua@mahidol.ac.th