Ammar Zidan and Süleyman Aşır Department of Materials Science and Nanotechnology Engineering, Near East University, Nicosia, Cyprus. ÖZ L iteratürde pek çok farklı nanorobot var ama bu derlemede bahsedeceğimiz nanorobot, tamamen bir kurbağanın kalp ve deri hücrelerinden yani sadece canlı hücrelerden oluşması nedeniyle benzersiz bir robot ve türünün ilk örneği. herhangi bir yapay malzeme olmadan. Bu tip robotlar, in vivo uygulanmadan önce kalp ve cilt hücrelerinin düzenleneceği silico sistemi kullanılarak programlanmış ve çalışılmıştır. Öte yandan, bu robotun birçok olumsuzluğu var, tıpkı dünyamızdaki her şeyin dezavantajları ve avantajları olduğu gibi, bu yüzden bu eşsiz robotun özlemlerinden ve gelecekteki yönlerinden bahsederek bu incelemede onlardan bahsedeceğiz ve tartışacağız. (A concise abstract briefly stating the purpose of the research, major findings, and conclusions, should appear here. Single-spaced, text flush left and right, 9 points not to exceed 6 lines. Maxi- mum 200 words). Anahtar Kelimeler Ksenobotlar, nanorobotlar, nanoteknoloji, yeniden yapılandırılabilir organizmalar, Xenopus laevis. ABSTRACT T here are many different nanorobots in the literature, but the nanorobots that we will talk about in this review is a unique robot and the first of their kind because it is made entirely from the heart and skin cells of a frog, which means only living cells without any artificial materials. This type of robot has been programmed and studied using the silico system, in which the heart and skin cells will be arranged before being applied in vivo have been designed. On the other hand, this robot has many negatives, like anything in our world has disadvantages and advantages, so we will mention them and discuss them in this review by mentioning the aspirations and future directions of this unique robot. Key Words Xenobots, nanorobots, nanotechnology, reconfigurable organisms, Xenopus laevis. Article History: Received: Dec 5, 2022; Revised: Jan 10, 2023; Accepted: Jan 11, 2023; Available Online: Jan 18, 2023. DOI: https://doi.org/10.15671/hjbc.1208034 Correspondence to: S. Aşır, Department of Materials Science and Nanotechnology Engineering, 99138, Near East University, Nicosia, Cyprus. E-Mail: asuleyman.asir@neu.edu.tr Programmable Living Nanorobots Programlanabilir Yaşayan Nanorobotlar Hacettepe Journal of Biology and Chemistry A. Zidan and S. Aşır / Hacettepe J. Biol. & Chem., 2023, (2), 183-190 Research Article journal homepage: www.hjbc.hacettepe.edu.tr